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Spectral-domain optical coherence tomography findings in polypoidal choroidal vasculopathy suggest a type 1 neovascular growth pattern

Authors Alshahrani S, Al Shamsi H, Saeed Kahtani E, Ghazi N

Received 27 May 2014

Accepted for publication 12 June 2014

Published 1 September 2014 Volume 2014:8 Pages 1689—1695

DOI https://doi.org/10.2147/OPTH.S68471

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4


Saeed T Alshahrani,1,2 Hanan N Al Shamsi,2 Eman S Kahtani,2 Nicola G Ghazi2,3

1King Fahad Specialist Hospital, Dammam, Saudi Arabia; 2King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 3University of Virginia, Department of Ophthalmology, Charlottesville, VA, USA

Purpose: To report spectral-domain optical coherence tomography (SD-OCT) findings in polypoidal choroidal vasculopathy (PCV).
Patients and methods: Seventeen eyes of 15 consecutive patients diagnosed with PCV based on typical clinical and angiographic findings were imaged with macular SD-OCT including line scans passing through the polyps.
Results: SD-OCT findings included typical and atypical retinal pigment epithelial (RPE) detachments and subretinal and intraretinal fluid in all eyes. In the areas corresponding to the polypoidal lesions, well-delineated round-oval, sub-RPE cavities were present and were adherent to the posterior surface of the detached RPE above Bruch membrane. No retinal or choroidal connections to the cavities were noted.
Conclusion: These SD-OCT findings document that the vascular lesions in PCV are not located in the inner choroid, but in the sub-RPE space, suggesting that PCV is a variant of type 1 choroidal neovascularization rather than a distinct clinical entity as initially thought.

Keywords: choroidal neovascularization, retinal pigment epithelial detachments, vascular lesion, SD-OCT, type 1 choroidal neovascularization

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