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Sodium valproate-induced enuresis in a pediatric bipolar patient

Authors Cheng W, Lin X, Lu D , Luo L

Received 22 August 2013

Accepted for publication 3 September 2013

Published 31 October 2013 Volume 2013:9 Pages 1671—1672


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Wentao Cheng,1,* Xiaoling Lin,2,* Dali Lu1

1Department of Pediatric and Geriatric Psychiatry, Fuzhou Neuropsychiatric Hospital, Fuzhou, Fujian, People's Republic of China; 2School of Nursing of Central South University, Changsha, Hunan, People's Republic of China

*These authors contributed equally to this work

Abstract: Sodium valproate (SV) is effective and well tolerated for the treatment of epilepsy and mood disorders. There are several cases of SV-induced enuresis noted in epileptic patients. No alternative medication has been suggested to manage this problem. We present the first case of a pediatric bipolar patient who developed diurnal and nocturnal enuresis during SV therapy. Clinicians should be aware of this side effect, as it has not been reported in nonepileptic patients, and it may be detrimental to treatment adherence.

Keywords: sodium valproate, enuresis, bipolar disorder

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