Silver-coated gold nanorods as a promising antimicrobial agent in the treatment of cancer-related infections
Authors Zhang J, Wang M, Webster TJ
Received 28 March 2018
Accepted for publication 16 July 2018
Published 17 October 2018 Volume 2018:13 Pages 6575—6583
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Thiruganesh Ramasamy
Peer reviewer comments 2
Editor who approved publication: Professor Carlos Rinaldi
Junyan Zhang,1 Mian Wang,1 Thomas J Webster1,2
1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China
Background: Many cancer patients suffer from cancer-related life-threatening infections due to immune system damage. Therefore, researchers are continuously looking for new options to treat cancer-related infections. As nanotechnology has gained tremendous interest over the past several decades, silver nanoparticles have been investigated as an effective antimicrobial agent. Here, silver-coated gold nanorods were synthesized to share similar optical properties as gold nanoparticles for cancer diagnosis and treatment, with an added advantage of antibacterial properties.
Results: Their dose-dependent antimicrobial properties were demonstrated on both Gram-negative and Gram-positive bacteria species. These nanorods were found to be highly efficient in killing bacteria and suppressing biofilm formation.
Conclusion: Collectively, such results suggest that silver-coated gold nanorods should be further investigated as a novel material, which can both decrease cancer cell functions and reduce the risk of infection for cancer patients.
Keywords: nanotechnology, bacteria, cancer cells, infrared excitation
This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.Download Article [PDF] View Full Text [HTML][Machine readable]