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Silver-coated gold nanorods as a promising antimicrobial agent in the treatment of cancer-related infections

Authors Zhang J, Wang M, Webster TJ

Received 28 March 2018

Accepted for publication 16 July 2018

Published 17 October 2018 Volume 2018:13 Pages 6575—6583

DOI https://doi.org/10.2147/IJN.S169489

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Thiruganesh Ramasamy

Peer reviewer comments 2

Editor who approved publication: Professor Carlos Rinaldi


Junyan Zhang,1 Mian Wang,1 Thomas J Webster1,2

1Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Wenzhou Institute of Biomaterials and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China

Background: Many cancer patients suffer from cancer-related life-threatening infections due to immune system damage. Therefore, researchers are continuously looking for new options to treat cancer-related infections. As nanotechnology has gained tremendous interest over the past several decades, silver nanoparticles have been investigated as an effective antimicrobial agent. Here, silver-coated gold nanorods were synthesized to share similar optical properties as gold nanoparticles for cancer diagnosis and treatment, with an added advantage of antibacterial properties.
Results: Their dose-dependent antimicrobial properties were demonstrated on both Gram-negative and Gram-positive bacteria species. These nanorods were found to be highly efficient in killing bacteria and suppressing biofilm formation.
Conclusion: Collectively, such results suggest that silver-coated gold nanorods should be further investigated as a novel material, which can both decrease cancer cell functions and reduce the risk of infection for cancer patients.

Keywords: nanotechnology, bacteria, cancer cells, infrared excitation

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