Back to Journals » Cancer Management and Research » Volume 11

Serum Fibrinogen Is An Independent Prognostic Factor In Operable Esophageal Squamous Carcinoma: A Real-World Study

Authors Zheng Y, Li Y, Xing W, Qin J, Liu X, Zhang R, Sun H, Chen X

Received 14 April 2019

Accepted for publication 18 September 2019

Published 11 October 2019 Volume 2019:11 Pages 8877—8883


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Rudolph Navari

Yan Zheng,1,* Yin Li,1,2,* Wenqun Xing,1,* Jianjun Qin,1,2 Xianben Liu,1 Ruixiang Zhang,1 Haibo Sun,1 Xiankai Chen1,2

1Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450008, People’s Republic of China; 2Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Yin Li
The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, 127# Dongming Road, Zhengzhou 450000, People’s Republic of China
Tel +86 371 65587226

Purpose: To fully elucidate the relationship of serum fibrinogen and the prognosis of esophageal squamous cell carcinoma.
Methods: The concentrations of serum fibrinogen were measured by the Clauss method in a total of 1331 operable esophageal squamous cell carcinoma (ESCC) patients from the past 3 years. The correlation of serum fibrinogen concentration and patient outcome and clinical pathological factors was tested.
Results: Hyperfibrinogenemia was significantly correlated with advanced pathological T stage and TNM stage. Serum fibrinogen was determined as a worse independent survival predictor in ESCC by survival analysis. The hazard ratio was 1.672 (95% confidence interval [CI] 1.043–2.681). A subgroup analysis further elucidated a significant correlation between hyperfibrinogenemia and younger age (P=0.011), being female (P=0.002), not having a history of smoking (p<0.001) or alcohol consumption (p<0.001), pathological N0 stage (P=0.002), and early pathological TNM stage (I-II) (P=0.004).
Conclusion: This research showed that preoperative serum fibrinogen is an independent prognostic factor for survival in ESCC, especially for the early pathological TNM stage (I-II) and N0 patients.

Keywords: esophageal cancer, serum fibrinogen, prognostic factor, retrospective study, real world study

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]