Serum Fibrinogen Is An Independent Prognostic Factor In Operable Esophageal Squamous Carcinoma: A Real-World Study
Authors Zheng Y, Li Y, Xing W, Qin J, Liu X, Zhang R, Sun H, Chen X
Received 14 April 2019
Accepted for publication 18 September 2019
Published 11 October 2019 Volume 2019:11 Pages 8877—8883
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Nicola Ludin
Peer reviewer comments 2
Editor who approved publication: Professor Rudolph Navari
Yan Zheng,1,* Yin Li,1,2,* Wenqun Xing,1,* Jianjun Qin,1,2 Xianben Liu,1 Ruixiang Zhang,1 Haibo Sun,1 Xiankai Chen1,2
1Department of Thoracic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan 450008, People’s Republic of China; 2Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yin Li
The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital, 127# Dongming Road, Zhengzhou 450000, People’s Republic of China
Tel +86 371 65587226
Purpose: To fully elucidate the relationship of serum fibrinogen and the prognosis of esophageal squamous cell carcinoma.
Methods: The concentrations of serum fibrinogen were measured by the Clauss method in a total of 1331 operable esophageal squamous cell carcinoma (ESCC) patients from the past 3 years. The correlation of serum fibrinogen concentration and patient outcome and clinical pathological factors was tested.
Results: Hyperfibrinogenemia was significantly correlated with advanced pathological T stage and TNM stage. Serum fibrinogen was determined as a worse independent survival predictor in ESCC by survival analysis. The hazard ratio was 1.672 (95% confidence interval [CI] 1.043–2.681). A subgroup analysis further elucidated a significant correlation between hyperfibrinogenemia and younger age (P=0.011), being female (P=0.002), not having a history of smoking (p<0.001) or alcohol consumption (p<0.001), pathological N0 stage (P=0.002), and early pathological TNM stage (I-II) (P=0.004).
Conclusion: This research showed that preoperative serum fibrinogen is an independent prognostic factor for survival in ESCC, especially for the early pathological TNM stage (I-II) and N0 patients.
Keywords: esophageal cancer, serum fibrinogen, prognostic factor, retrospective study, real world study
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