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Sensitization to Common Allergens Among Children with Asthma and Allergic Rhinitis in Qatar

Authors Zahraldin K, Chandra P, Tuffaha A, Ehlayel M

Received 2 December 2020

Accepted for publication 8 March 2021

Published 29 March 2021 Volume 2021:14 Pages 287—292

DOI https://doi.org/10.2147/JAA.S295228

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Editor who approved publication: Dr Luis Garcia-Marcos


Khalid Zahraldin,1 Prem Chandra,2 Amjad Tuffaha,3,4 Mohammad Ehlayel4,5

1Section of Pediatric Pulmonology, Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar; 2Department of Statistics, Medical Research Center, Hamad Medical Corporation, Doha, Qatar; 3Division of Pediatric Pulmonology, Sidra Medicine, Doha, Qatar; 4Department of Pediatrics, Weill-Cornell-Medical College- Qatar, Ar-Rayan, Qatar; 5Section of Pediatric Allergy-Immunology, Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar

Correspondence: Mohammad Ehlayel
Section of Pediatric Allergy-Immunology, Department of Pediatrics, Hamad Medical Corporation, PO Box 3050, Doha, Qatar
Tel +974 4439 2834
Fax +974 4443 9571
Email [email protected]

Background: Childhood asthma (A) and allergic rhinitis (AR) are common in Qatar. Aeroallergens sensitization is integral in disease pathogenesis and clinical presentation. Determining sensitization patterns assists clinicians in tailoring an efficient medical management.
Objective: To determine the aeroallergen sensitization pattern and relationship to clinical parameters.
Methods: A retrospective review of children (2– 14-years) files with i) Pediatric Allergist/or Pulmonologist confirmed-diagnosis of A, and AR, and ii) positive skin prick test (SPT).
Results: Among 473 patients (69.1% males; 30.9% females), aged 7.6 years, family history was positive in 66.3%: 59.4% in A, 64.2% AR, and 78.2% A-AR. The number of allergens/patients was 2.1± 1.7. Median eosinophil count was 400 cells/ul and IgE 287 KU/L. Rates of A, AR, and A-AR varied significantly in children ≤ 5 years compared to > 10 years: A was 43.2% vs 17.8%, and AR 34.5% vs 16.4%. Two hundred and four children (43.1%) were mono-sensitized, 215 (45.5%) oligosensitized (2– 3 allergens), and 54 (11.4%) polysensitized (≥ 4 allergens). A-AR ranked the top number of positive allergens. The commonest aeroallergen was Der p1 (38.1%), followed by Der f (29.0%), cat (22.6%), alternaria (18.8%), American cockroach (18.4%), and dog (14.0%). House dust mite (HDM) and American cockroach were commoner in ≤ 5 years than older > 10-year children (52.5%, 24.1%), while cat and dog allergens were commoner in older ones (37.1%, 21.6%).
Conclusion: Family history is quite positive in patients with A and AR. Common aeroallergens include HDM, cats, and alternaria in the young children, while animal allergens were commoner in the older children.

Keywords: asthma, allergic rhinitis, skin prick test, children

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