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Secondhand smoking increases bladder cancer risk in nonsmoking population: a meta-analysis

Authors Yan H, Ying Y, Xie H, Li J, Wang X, He L, Jin K, Tang J, Xu X, Zheng X

Received 23 May 2018

Accepted for publication 13 July 2018

Published 21 September 2018 Volume 2018:10 Pages 3781—3791

DOI https://doi.org/10.2147/CMAR.S175062

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Professor Raphael Catane


Huaqing Yan, Yufan Ying, Haiyun Xie, Jiangfeng Li, Xiao Wang, Liujia He, Ke Jin, Jianer Tang, Xin Xu, Xiangyi Zheng

Department of Urology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China

Background: Tobacco smoking has been widely acknowledged to be the most important risk factor for bladder cancer. However, whether secondhand smoking (SHS) increases the risk of bladder cancer still remains uncertain. We conducted a meta-analysis about the risk of bladder cancer and lifetime SHS and childhood SHS.
Materials and methods: We searched PubMed, EMBASE, Web of Science, and Chinese National Knowledge Infrastructure (CNKI) up to March 12, 2018, and checked references of the retrieved articles and relevant reviews to include 14 studies. Relative risk (RR) and 95% confidence interval (CI) were used to assess this risk.
Results: The pooled RR of 14 eligible studies based on the retrieved articles and relevant reviews illustrated a significantly increased risk of bladder cancer with RR 1.22, 95% CI 1.06–1.4. No heterogeneity or publication bias was found. But we need more evidence to prove a more reliable association between childhood SHS and bladder cancer.
Conclusion: There was a statistically significant 22% increased risk of bladder cancer for lifetime SHS exposure in nonsmoking patients compared with unexposed nonsmoking population. But the association between childhood SHS exposure compared with unexposed nonsmoking population was unclear. Further research should be conducted to confirm our findings and reveal the potential biological mechanisms.

Keywords: environmental smoking, bladder tumor, nonsmoking adult, childhood exposure

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