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Searching for the relationship between the parameters of metabolic syndrome and the rs17782313 (T>C) polymorphism of the MC4R gene in postmenopausal women

Authors Brodowski J, Szkup M, Jurczak A, Wieder-Huszla S, Brodowska A, Laszczyńska M, Karakiewicz B, Kęcka K, Grochans E

Received 10 December 2016

Accepted for publication 1 February 2017

Published 22 March 2017 Volume 2017:12 Pages 549—555

DOI https://doi.org/10.2147/CIA.S129874

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Richard Walker


Jacek Brodowski,1 Małgorzata Szkup,2 Anna Jurczak,2 Sylwia Wieder-Huszla,2 Agnieszka Brodowska,3 Maria Laszczyńska,4 Beata Karakiewicz,5 Katarzyna Kęcka,1 Elżbieta Grochans2

1Primary Care Department, Pomeranian Medical University in Szczecin, 2Department of Nursing, Pomeranian Medical University in Szczecin, 3Clinic of Gynecology, Endocrinology, and Gynecologic Oncology, Pomeranian Medical University in Szczecin, 4Department of Histology and Developmental Biology, Pomeranian Medical University in Szczecin, 5Public Health Department, Pomeranian Medical University in Szczecin, Żołnierska, Szczecin, Poland

Abstract: Metabolic syndrome (MS) is widespread in the human population, and its incidence is continuously increasing, generating serious health problems. The purpose of this study was to find the relationship between the parameters of MS and the melanocortin type 4 receptor (MC4R) gene polymorphism in postmenopausal women. The study involved 344 healthy Polish women, who had their last menstrual cycle 1 year ago or earlier. The study included blood analysis, survey, and body measurements. The mean age was 58.5±6.6 years. An increased body mass index was observed in 65.7% and abdominal obesity in 80.3% of the study population. MS was diagnosed in 40.7% of all participants, including 39.3% of women with the T/T genotype and 44.7% of those with the C/X genotype (χ2 test; P>0.05). A logistic regression model showed that the probability of MS was higher in patients with the C/X genotype (odds ratio =1.25) (χ2 test; P>0.05). The study concluded that MS is a very common condition among postmenopausal women. The C/X genotype of the MC4R gene seems to predispose postmenopausal women to developing some MS symptoms.

Keywords: melanocortin type 4 receptor (MC4R), postmenopausal women, metabolic syndrome

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