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Safety and tolerability of tafluprost in treatment of elevated intraocular pressure in open-angle glaucoma and ocular hypertension

Authors Pozarowska D

Published 19 October 2010 Volume 2010:4 Pages 1229—1236

DOI https://doi.org/10.2147/OPTH.S6369

Review by Single-blind

Peer reviewer comments 2

Dorota Pozarowska
Department of Ophthalmology, Medical University, Lublin, Poland

Abstract: Glaucoma is one of the most common neuropathies of the optic nerve. An elevated intraocular pressure (IOP) is a well documented risk factor for the development and progression of this disease. Until now, IOP reduction is the only well documented successful method of glaucoma treatment. Among the many hypotensive drugs, prostaglandin analogs are proved to be the most potent antiglaucoma agents, with very few systemic side effects. A new prostanoid FP receptor analog, tafluprost, has been introduced into the medical treatment of glaucoma and ocular hypertension. Many studies have shown that it is an efficient IOP-lowering drug, and that it is safe and well tolerated. A preservative-free tafluprost formulation is as potent as a preserved one, but it has fewer and milder toxic effects on the eye.

Keywords: tafluprost, prostaglandins, pharmacokinetics, safety, toxic effects, preservatives

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