Role of TGF-β on cardiac structural and electrical remodeling
Roberto Ramos-Mondragón, Carlos A Galindo, Guillermo Avila
Departamento de Bioquímica, Cinvestav-IPN, México
Abstract: The type β transforming growth factors (TGF-βs) are involved in a number of human diseases, including heart failure and myocardial arrhythmias. In fact, during the last 20 years numerous studies have demonstrated that TGF-β affects the architecture of the heart under both normal and pathological conditions. Moreover, TGF-β signaling is currently under investigation, with the aim of discovering potential therapeutic roles in human disease. In contrast, only few studies have investigated whether TGF-β affects electrophysiological properties of the heart. This fact is surprising since electrical remodeling represents an important substrate for cardiac disease. This review discusses the potential role of TGF-β on cardiac excitation-contraction (EC) coupling, action potentials, and ion channels. We also discuss the effects of TGF-β on cardiac development and disease from structural and electrophysiological points of view.
Keywords: transforming growth factor, ion channel, cardiac electrophysiology
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