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Role of adipose tissue in facial aging

Authors Wollina U, Wetzker R, Abdel-Naser MB, Kruglikov IL

Received 13 September 2017

Accepted for publication 1 November 2017

Published 6 December 2017 Volume 2017:12 Pages 2069—2076

DOI https://doi.org/10.2147/CIA.S151599

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Richard Walker


Uwe Wollina,1 Reinhard Wetzker,2 Mohamed Badawy Abdel-Naser,3 Ilja L Kruglikov4

1Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, 2Department of Anesthesiology and Intensive Care Medicine, and Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany; 3Department of Dermatology and Venereology, Ain Shams University Hospital, Cairo, Egypt; 4Wellcomet GmbH, Karlsruhe, Germany

Abstract: Age-dependent modification of the facial subcutaneous white adipose tissue (sWAT) connected with reduction of its volume, modification of collagen content and adhesion between dermal and adipose layers can significantly influence mechanical stability of the skin and cause the development of aging symptoms such as wrinkles. Typical aging appearance in facial skin is at least partly connected with special phenotypical features of facial preadipocytes and mature adipocytes. In this paper, we have discussed the possible roles of local inflammation, compartmental structure of facial sWAT and trans-differentiation processes such as beiging of white adipocytes and adipocyte-myofibroblast transition in facial skin aging.

Keywords: facial aging, adipose tissue, preadipocytes, adipocytes, inflammation, beiging, adipocyte-myofibroblast transition
 

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