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Risk factors for gallbladder contractility after cholecystolithotomy in elderly high-risk surgical patients

Authors Wang T, Luo H, Yan H, Zhang G, Liu W, Tang L

Received 20 October 2016

Accepted for publication 8 December 2016

Published 12 January 2017 Volume 2017:12 Pages 129—136

DOI https://doi.org/10.2147/CIA.S125139

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Dr Wu


Tao Wang,* Hao Luo,* Hong-tao Yan,* Guo-hu Zhang, Wei-hui Liu, Li-jun Tang

General Surgery Center, Chengdu Military General Hospital, Chengdu, Sichuan, People’s Republic of China

*These authors contributed equally to this work

Objective:
Cholecystolithiasis is a common disease in the elderly patient. The routine therapy is open or laparoscopic cholecystectomy. In the previous study, we designed a minimally invasive cholecystolithotomy based on percutaneous cholecystostomy combined with a choledochoscope (PCCLC) under local anesthesia.
Methods: To investigate the effect of PCCLC on the gallbladder contractility function, PCCLC and laparoscope combined with a choledochoscope were compared in this study.
Results: The preoperational age and American Society of Anesthesiologists (ASA) scores, as well as postoperational lithotrity rate and common biliary duct stone rate in the PCCLC group, were significantly higher than the choledochoscope group. However, the pre- and postoperational gallbladder ejection fraction was not significantly different. Univariable and multivariable logistic regression analyses indicated that the preoperational thickness of gallbladder wall (odds ratio [OR]: 0.540; 95% confidence interval [CI]: 0.317–0.920; P=0.023) and lithotrity (OR: 0.150; 95% CI: 0.023–0.965; P=0.046) were risk factors for postoperational gallbladder ejection fraction. The area under receiver operating characteristics curve was 0.714 (P=0.016; 95% CI: 0.553–0.854).
Conclusion: PCCLC strategy should be carried out cautiously. First, restricted by the diameter of the drainage tube, the PCCLC should be used only for small gallstones in high-risk surgical patients. Second, the usage of lithotrity should be strictly limited to avoid undermining the gallbladder contractility and increasing the risk of secondary common bile duct stones.

Keywords: cholecystolithotomy, lithotrity, thickness of gallbladder wall, GBEF, gallbladder motility

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