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Reviews of botulinum toxin products in aesthetic use must be accurate, clear and avoid speculation

Authors Pickett A

Received 23 April 2013

Accepted for publication 24 April 2013

Published 5 September 2013 Volume 2013:5(1) Pages 149—152

DOI https://doi.org/10.2147/CPAA.S47086

Checked for plagiarism Yes


Andy Pickett1,2

1Toxin Science Limited, Wrexham, UK; 2Botulinum Research Center, University of Massachusetts (UMASS), North Dartmouth, MA, USA

One of the most surprising and, at the same time, most frustrating aspects of the continual rise in the use of botulinum toxin type A (BoNT-A), particularly in aesthetic applications, is the sheer number of reviews currently being published. So far in 2013, there have been seven single or joint reviews of BoNT products focusing on facial aesthetics. The frustrating aspects of these reviews cover two areas: Firstly, they inevitably speculate about why there are "apparent differences" between the products. They attempt to use the science of BoNT-A to explain these differences. This speculation is both inappropriate and weak. In fact, the majority of differences between the products seen clinically are, by far, due to simple dose differences used in studies, especially when two or more products are being compared.

View original paper by Prager.

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