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Review of Curcumin Physicochemical Targeting Delivery System

Authors Li L, Zhang X, Pi C, Yang H, Zheng X, Zhao L, Wei Y

Received 9 August 2020

Accepted for publication 21 October 2020

Published 7 December 2020 Volume 2020:15 Pages 9799—9821

DOI https://doi.org/10.2147/IJN.S276201

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Prof. Dr. Thomas J. Webster


Lanmei Li,1,2,* Xiaomei Zhang,3,* Chao Pi,1 Hongru Yang,4 Xiaoli Zheng,5 Ling Zhao,1 Yumeng Wei1

1Central Nervous System Drug Key Laboratory of Sichuan Province, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, People’s Republic of China; 2Nanchong Key Laboratory of Individualized Drug Therapy, Department of Pharmacy, The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan 637000, People’s Republic of China; 3Institute of Medicinal Chemistry of Chinese Medicine, Chongqing Academy of Chinese MateriaMedica, Chongqing 400065, People’s Republic of China; 4Department of Oncology of Luzhou People’s Hospital, Luzhou, Sichuan 646000, People’s Republic of China; 5Basic Medical College of Southwest Medical University, Luzhou, Sichuan 646000, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Ling Zhao; Yumeng Wei
School of Pharmacy, Southwest Medical University, No. 3-319, Zhongshan Road, Jiangyang District, Luzhou City, Sichuan Province 646000, People’s Republic of China
Tel/Fax +86 830 3162292
Email zhaoling-998@163.com; weiyumeng-268@163.com

Abstract: Curcumin (CUR), as a traditional Chinese medicine monomer extracted from the rhizomes of some plants in Ginkgo and Araceae, has shown a wide range of therapeutic and pharmacological activities such as anti-tumor, anti-inflammatory, anti-oxidation, anti-virus, anti-liver fibrosis, anti-atherosclerosis, and anti-Alzheimer’s disease. However, some issues significantly affect its biological activity, such as low aqueous solubility, physico-chemical instability, poor bioavailability, and low targeting efficacy. In order to further improve its curative effect, numerous efficient drug delivery systems have been carried out. Among them, physicochemical targeting preparations could improve the properties, targeting ability, and biological activity of CUR. Therefore, in this review, CUR carrier systems are discussed that are driven by physicochemical characteristics of the microenvironment (eg, pH variation of tumorous tissues), affected by external influences like magnetic fields and vehicles formulated with thermo-sensitive materials.

Keywords: curcumin, targeted delivery system, pH-sensitive, magnetic-response, thermo-sensitive, cancer

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