Antitumor Effect of Triptolide in T-Cell Lymphoblastic Lymphoma by Inhibiting Cell Viability, Invasion, and Epithelial–Mesenchymal Transition via Regulating the PI3K/AKT/mTOR Pathway [Retraction]

Huang Y, Wu S, Zhang Y, Wang L, Guo Y. Onco Targets Ther. 2018;11:769-779.

At the author’s request, we, the Editors and Publisher of OncoTargets and Therapy, have retracted the following article.

Following publication of the article, concerns were raised about the duplication of images from Figures 2, 3, 4, 5 and 6 with images from other unrelated articles. Specifically,

• Images in Figure 2C and 5A have been duplicated with images for Figure 1C from Li B, Wang F, Liu N, Shen W, Huang T. Astragaloside IV inhibits progression of glioma via blocking MAPK/ERK signaling pathway. Biochemical and Biophysical Research Communications. 2017;491:98-103. https://doi.org/10.1016/j.bbrc.2017.07.052 and Han Y, Ma J, Wang J, Wang L. Silencing of H19 inhibits the adipogenesis and inflammation response in ox-LDL-treated Raw264.7 cells by up-regulating miR-130b. Molecular Immunology. 2018;93:107-114. https://doi.org/10.1016/j.molimm.2017.11.017.
• Images for Figure 3A have been duplicated with images for Figures 1C and 1D from Tian L, Zhao Z, Xie L, Zhu J. RETRACTED: MiR-361-5p inhibits the mobility of gastric cancer cells through suppressing epithelial-mesenchymal transition via the Wnt/β-catenin pathway. Gene. 2018;675:102-109. https://doi.org/10.1016/j.gene.2018.06.095 and Figure 5 from Kong Y, Zhao S, Tian H, Hai Y. GAS2 Promotes Cell Proliferation and Invasion and Suppresses Apoptosis in Pediatric T-Cell Acute Lymphoblastic Leukemia and Activates Wnt/β-Catenin Pathway. Onco Targets Ther. 2020;13:1099-1108. https://doi.org/10.2147/OTT.S236854.
• Images for Figure 4D have been duplicated with images for Figure 2C from Li B, et al (2017); Figure 2C from Han Y, et al (2018) and Figure 5B from Ke Y, Chen L, Zhou M, et al. Resveratrol enhances chemosensitivity of renal cell carcinoma to paclitaxel. Front. Biosci. (Landmark Ed). 2019;24(8):1452–1461. https://doi.org/10.2741/4790.
• Images for Figure 6D have been duplicated with images for 3A from Jia L, Huang S, Yin X, Zan Y, Guo Y, Han L. Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction. Life Sciences. 2018;208:123-130. https://doi.org/10.1016/j.lfs.2018.07.027; Figure 3B from Gu J, Cui C, Yang L, Wang L, Jiang X. Emodin Inhibits Colon Cancer Cell Invasion and Migration by Suppressing Epithelial–Mesenchymal Transition via the Wnt/β-Catenin Pathway. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics. 2019;27:193-202. https://doi.org/10.3727/096504018X15150662230295 and Figure 5C from Han Y, et al (2018).
• In addition, images for Figure 5B, Control group and TPL 20 nM, have been duplicated.

The authors responded to our queries but were unable to provide a satisfactory explanation for the duplicated images or provide satisfactory data for the study. As verifying the validity of published work is core to the integrity of the scholarly record, the authors requested to retract the article and the Editor and Publisher agreed with this decision.

We have been informed in our decision-making by our editorial policies and COPE guidelines.

The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.