Back to Journals » Drug Design, Development and Therapy » Volume 10

Resolvins and aliamides: lipid autacoids in ophthalmology – what promise do they hold?

Authors Hesselink JMK, Chiosi F, Costagliola C

Received 9 May 2016

Accepted for publication 7 July 2016

Published 27 September 2016 Volume 2016:10 Pages 3133—3141

DOI https://doi.org/10.2147/DDDT.S112389

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Palas Chanda

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Frank Boeckler

Jan M Keppel Hesselink,1 Flavia Chiosi,2 Ciro Costagliola2

1University of Witten/Herdecke, Witten, Germany; 2Eye Clinic, Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy

Abstract: Resolvins are a novel class of lipid-derived endogenous molecules (autacoids) with potent immunomodulating properties, which regulate the resolution phase of an active immune response. These modulating factors are locally produced, influencing the function of cells and/or tissues, which are produced on demand and subsequently metabolized in the same cells and/or tissues. This review is focused on certain lipid autacoids with putative relevance for ophthalmology in general and for dry eye more specifically. We also briefly investigate the concept of aliamides and the role of palmitoylethanolamide in ophthalmology, and analyze in more detail the putative role and the preclinical and clinical development of resolvins as emerging treatments for dry eye and related disorders, with a focus on one of the lead resolvin derivatives – RX-10045.

Keywords: resolvins, autacoids, aliamides, dry eye, palmitoylethanolamide, inflammation, ophthalmology, protection

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]