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Research Progress Evaluating the Function and Mechanism of Anti-Tumor Peptides

Authors Pan X, Xu J, Jia X

Received 27 September 2019

Accepted for publication 8 December 2019

Published 16 January 2020 Volume 2020:12 Pages 397—409

DOI https://doi.org/10.2147/CMAR.S232708

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Harikrishna Nakshatri


Video abstract presented by Xuemei Jia.

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Xinxing Pan, Juan Xu, Xuemei Jia

Department of Gynecology, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province, People’s Republic of China

Correspondence: Xuemei Jia
Department of Gynecology, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, 123 Tianfeixiang, Mochou Road, Nanjing 210004, Jiangsu Province, People’s Republic of China
Tel/Fax +86-25-84460507
Email xmjia@njmu.edu.cn

Abstract: Malignant tumors cause a high mortality rate worldwide, and they severely threaten human health and negatively affect the economy. Despite the advancements in tumor-related molecular genetics and effective new processes in anti-tumor drug development, the anti-tumor drugs currently used in clinical practice are inadequate due to their poor efficacy or severe side effects. Therefore, developing new safe and efficient drugs is a top priority for curing cancer. The peptide has become a suitable agent due to its exact molecular weight between whole protein and small molecule, and it has high targeting ability, high penetrability, low immunogenicity, and is convenient to synthesize and easy to modify. Because of these advantages, peptides have excellent prospect for application as anti-tumor agents. This article reviews the recent research progress evaluating anti-tumor peptides and their anti-tumor mechanisms, and may act as a reference for the future development and clinical application of anti-tumor peptides.

Keywords: anti-cancer, small biomolecule, medicine, drug development

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