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Renal transplantation in patients with Alport syndrome: patient selection, outcomes, and donor evaluation

Authors Kashtan CE

Received 2 June 2018

Accepted for publication 15 August 2018

Published 16 October 2018 Volume 2018:11 Pages 267—270

DOI https://doi.org/10.2147/IJNRD.S150539

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 4

Editor who approved publication: Professor Pravin Singhal


Clifford E Kashtan

Division of Nephrology, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55454, USA

Abstract: Alport syndrome is an inherited disorder of basement membrane collagen IV that frequently results in end-stage renal disease. Patients with Alport syndrome who undergo renal transplantation have generally excellent outcomes. Posttransplant antiglomerular basement membrane nephritis is a rare complication of renal transplantation for Alport syndrome. Because Alport syndrome is a genetic disorder, potential related donors must be carefully evaluated in order to minimize harm.

Keywords: Alport syndrome, kidney transplantation, collagen IV, posttransplant anti-GBM nephritis
 

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