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Remarkable inhibitory effects of hybrid liposomes on growth of human colon cancer cells through induction of cell cycle arrest along with apoptosis

Authors Komizu Y, Ueoka H, Goto K, Ueoka R

Published 8 September 2011 Volume 2011:6 Pages 1913—1920

DOI https://doi.org/10.2147/IJN.S24160

Review by Single-blind

Peer reviewer comments 3

Yuji Komizu, Hidetsugu Ueoka, Koichi Goto, Ryuichi Ueoka
Division of Applied Life Science, Graduate School of Engineering, Sojo University, Ikeda, Kumamoto, Japan

Background: Hybrid liposomes can be prepared by simply sonicating a mixture of vesicular and micellar molecules in buffer solutions. In this study, we investigated the effects of hybrid liposomes on the growth of human colon cancer cells in vitro.
Methods: Hybrid liposomes (HL-n, n = 21, 23, 25) composed of L-α-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene(n) dodecyl ethers (C12(EO)n, n = 21, 23, 25) were prepared by the sonication method and their inhibitory effects on growth of human colon cancer HCT116 cells were examined in vitro.
Results: Significant growth inhibition of HCT116 cells was observed in the presence of HL-n. The fifty percent inhibitory concentration (IC50) of HL-n was less than half that of DMPC liposomes. Furthermore, fluorescence microscopic and flow cytometric analyses indicated that the markedly inhibitory effects of HL-n on the growth of HCT116 cells could be attained through the induction of cell cycle arrest at the G0/G1 phase along with apoptotic cell death.
Conclusion: It was found for the first time that HL-n can induce both cell cycle arrest and apoptosis in colon cancer cells. The findings in this study should contribute to novel chemotherapy for colon cancer.

Keywords: hybrid liposome, colon cancer cell, cell cycle arrest, apoptosis

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