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Relationship of quadriceps muscle power and optimal shortening velocity with angiotensin-converting enzyme activity in older women

Authors Kostka J, Sikora J, Kostka T

Received 15 July 2017

Accepted for publication 26 August 2017

Published 19 October 2017 Volume 2017:12 Pages 1753—1760

DOI https://doi.org/10.2147/CIA.S146494

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Richard Walker


Joanna Kostka,1,2 Joanna Sikora,3 Tomasz Kostka1

1Department of Geriatrics, Healthy Ageing Research Centre, 2Department of Physical Medicine, 3Laboratory of Bioanalysis, Department of Pharmaceutical Chemistry, Drug Analysis and Radiopharmacy, Medical University of Lodz, Lodz, Poland

Background: The goal of this study was to assess whether angiotensin-converting enzyme (ACE) activity is related to muscle function (strength, power and velocity), as well as to assess if ACE inhibitors (ACEIs) and other angiotensin system blocking medications (ASBMs) influence muscle performance in elderly women.
Subjects and methods: Ninety-five community-dwelling elderly women took part in this study. Anthropometric data, blood ACE activity analysis, maximum power (Pmax) and optimal shortening velocity (υopt) of the knee extensor muscles, handgrip strength, physical activity (PA) and functional performance were measured.
Results: Women taking ACEI were on average almost 2 years older than the women who did not take ACEI. They took more medicines and were also characterized by significantly lower level of ACE, but they did not differ in terms of PA level, results of functional performance and parameters characterizing muscle functions. No correlations of ACE activity with Pmax and handgrip strength, as well as with PA or functional performance were found. Higher ACE activity was connected with lower υopt for women who did not take any ASBMs (rho =−0.37; p=0.01).
Conclusion: Serum ACE activity was not associated with muscle strength, power and functional performance in both ASBM users and nonusers, but was associated with optimal shortening velocity of quadriceps muscles in older women. Further prospective studies are needed to assess if ACEIs or other ASBMs may slow down the decline in muscle function and performance.

Keywords: sarcopenia, frailty, muscle strength, functional performance, aging, ACE inhibitors
 

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