Back to Journals » Research Reports in Clinical Cardiology » Volume 5

Relationship between plasma apolipoprotein B concentrations and LDL particle number

Authors Morris P, McLain K, Malave H, Underberg J, Le N, Shapiro M, Winegar D, Pourfarzib R

Received 11 April 2014

Accepted for publication 30 May 2014

Published 18 September 2014 Volume 2014:5 Pages 237—242


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Pamela B Morris,1 Kellie H McLain,1 Hector A Malave,2 James A Underberg,3 Ngoc-Anh Le,4 Michael D Shapiro,5 Deborah A Winegar,6 Ray Pourfarzib6

1Division of Cardiology, Medical University of South Carolina, Charleston, SC, USA; 2Cardiology of Atlanta, Atlanta, GA, USA; 3Department of Medicine, New York University Langone Medical Center, New York, NY, USA; 4Atlanta Veterans Affairs Medical Center, Decatur, GA, USA; 5Oregon Health and Science University, Portland, OR, USA; 6LipoScience, Inc., Raleigh, NC, USA

Abstract: Many subjects with relatively normal, or even optimal, levels of low-density lipoprotein cholesterol (LDL-C) have increased atherogenic lipoprotein particle concentrations (apolipoprotein B [apoB] and LDL particle number [LDL-P] determined by nuclear magnetic resonance spectroscopy [NMR]). Numerous analyses have demonstrated that apoB and LDL-P predict the risk of future cardiovascular events more robustly than LDL-C, as estimated using the Friedewald equation. Little is known about the relationship between an individual's apoB and LDL-P level, and whether the relationship is comparable at different levels of LDL-C. The aim of this study was to examine the correlation between plasma apoB and LDL-P levels and specifically to evaluate the heterogeneity of LDL-P at low levels of apoB (< the 20th population percentile [78 mg/dL]). Data were derived from a group of consecutive patients added to a large, single laboratory database (LipoScience, Inc.) during a 1-week period in which a standard lipid profile, apoB, and LDL-P levels were available. When risk categories were assigned to the subjects using the Framingham Offspring Study's population percentiles for apoB and LDL-P, there was good agreement between the two measures when LDL-C levels were high (≥160 mg/dL). However, among individuals with low LDL-C and apoB, NMR analysis could identify a subgroup of individuals with potentially greater cardiovascular risk, as suggested by unexpected elevations in LDL-P.

Keywords: apolipoprotein B, LDL particle number, nuclear magnetic resonance spectroscopy, lipoproteins

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]