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Refractory Kawasaki disease: diagnostic and management challenges

Authors Duignan S, Doyle SL, McMahon CJ

Received 28 December 2018

Accepted for publication 23 May 2019

Published 30 October 2019 Volume 2019:10 Pages 131—139


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Roosy Aulakh

Sophie Duignan,1,2 Sarah L Doyle,2 Colin J McMahon1,2

1Department of Paediatric Cardiology, Our Lady’s Children’s Hospital, Dublin 12, Ireland; 2Department of Immunology, National Children’s Research Centre, Dublin, Ireland

Correspondence: Colin J McMahon
Department of Paediatric Cardiology, Our Lady’s Children’s Hospital, Crumlin, Dublin 12, Ireland
Tel +3 531 428 2854
Fax +3 531 409 6181
Email [email protected]

Abstract: Kawasaki disease (KD), an acute, self-limiting, medium-sized arterial vasculitis, is now the most common cause of acquired heart disease in childhood in the developed world. In this review, we discuss the diagnosis of KD, predicting resistance to traditional therapy and treatment options in refractory or high-risk disease. We also highlight ongoing clinical trials and other potential avenues of research which may prove beneficial in managing children, especially those with resistant KD.

Keywords: aneurysm, arteritis, coronary, inflammation, Kawasaki, vasculitis

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