Back to Journals » Clinical, Cosmetic and Investigational Dermatology » Volume 10

Recommendations for volume augmentation and rejuvenation of the face and hands with the new generation polycaprolactone-based collagen stimulator (Ellansé®)

Authors de Melo F, Nicolau P, Piovano L, Lin SL, Baptista-Fernandes T, King MI, Camporese A, Hong KK, Khattar MM, Christen MO

Received 29 June 2017

Accepted for publication 14 September 2017

Published 8 November 2017 Volume 2017:10 Pages 431—440


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Jeffrey Weinberg

Francisco de Melo,1 Pierre Nicolau,2 Luca Piovano,3 Shang-Li Lin,4 Tiago Baptista-Fernandes,5 Martyn I King,6 Alessandra Camporese,7 Kyungkook Hong,8 Maria M Khattar,9 Marie-Odile Christen10

1Zo Skin Centre, Dubai, United Arab Emirates; 2Clinica Dr P Nicolau, Figueres (Girona), Spain; 3Piovano Medical Center, Roma, Italy; 4Shang-Li Dermatologic & Aesthetic Clinic, New Taipei City, Taiwan, Republic of China; 5Instituto Portugues de Crurgia Plastica, Lisboa, Portugal; 6Cosmedic Skin Clinic, Tamworth, Staffordshire, UK; 7Studio Medico, Cadoneghe Padova, Italy; 8Hus-hu Dermatology Clinic, Seoul, South Korea; 9Aesthetica Clinic, Dubai, United Arab Emirates; 10Behavior, Paris, France

Background: The range of fillers currently available for soft-tissue augmentation is constantly expanding. The latest advances in filler technology include collagen biostimulators that exert their esthetic effect by promoting neocollagenesis. One such product is the next-generation collagen biostimulator (Ellansé®) that demonstrates properties as yet unseen in soft-tissue fillers. It is composed of polycaprolactone (PCL) microspheres in an aqueous carboxymethylcellulose gel carrier. Given its specific characteristics and the number of areas that can be treated with this innovative product, experts’ recommendations were deemed necessary and are therefore presented in this paper with a specific focus on the indications, treatment areas and procedures as well as injection techniques.
Methods: A multinational, multidisciplinary group of plastic surgeons and dermatologists convened to develop recommendations with a worldwide perspective. This publication provides information on the specific characteristics of the product and focuses on the recommendations on the injection techniques.
Results: Recommendations on injection techniques are provided for the upper face, mid-face and lower face and zone by zone for each of these areas, as well as hands. Based on the particular anatomy of each area, the focus is on the techniques and devices of injection and the volume and depth of injection. The information is tabulated, and photos are presented for illustration.
These recommendations provide a guideline for physicians who wish to perform safe and efficacious treatment with the PCL collagen stimulator for face and rejuvenation with volume augmentation.

Keywords: collagen stimulator, volumizer, polycaprolactone-Ellansé®, dermal filler, expert recommendations, injection techniques

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]