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Recent advances in clinical application of optical coherence tomography of human skin

Authors Gambichler T, Pljakic A, Schmitz L

Received 31 December 2014

Accepted for publication 23 February 2015

Published 7 July 2015 Volume 2015:8 Pages 345—354

DOI https://doi.org/10.2147/CCID.S69119

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Dr Jeffrey Weinberg


Thilo Gambichler, Azem Pljakic, Lutz Schmitz

Department of Dermatology, Ruhr-University Bochum, Bochum, Germany

Abstract: Optical coherence tomography (OCT) is an emerging noninvasive imaging method that uses infrared light and interferometric techniques. The method has become increasingly popular in skin research as well as daily dermatology practice. In the present brief review, we focused on recent (2009–2014) OCT studies on the human skin, which included a reasonable sample size and statistics. Twenty-five papers were selected and briefly described OCT of epidermal thickness, skin appendages, wound healing, extracellular matrix and skin fibrosis, vascular malformations, and skin tumors such as basal cell carcinoma, actinic keratoses, and malignant melanoma.

Keywords: optical coherence tomography, dermatology, skin imaging, interferometry, histology

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