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Real-World Treatment Patterns of Disease Modifying Therapy (DMT) for Patients with Relapse-Remitting Multiple Sclerosis and Patient Satisfaction with Therapy: Results of the Non-Interventional SKARLET Study in Slovakia

Authors Turčáni P, Mašková J, Húska J

Received 24 March 2020

Accepted for publication 20 June 2020

Published 7 July 2020 Volume 2020:14 Pages 1129—1135

DOI https://doi.org/10.2147/PPA.S254427

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Johnny Chen


Peter Turčáni,1 Jana Mašková,2 Jozef Húska3

1First Department of Neurology, Faculty of Medicine, Comenius University, Bratislava 81369, Slovak Republic; 2NEOX Clinical Research, Prague 1 110 00, Czech Republic; 3Sanofi-Aventis Slovakia, Bratislava 851 01, Slovak Republic

Correspondence: Jozef Húska Email jozef.huska@sanofi.com

Background: During long-term multiple sclerosis therapy, patient satisfaction with received treatment has considerable impact on treatment outcomes. Here we report the results of a non-interventional real-world study that mapped the treatment patterns of disease-modifying therapy (DMT) and assessed treatment satisfaction with DMT.
Patients and Methods: The SKARLET study was a non-interventional, cross-sectional study in Slovakia running from May 2016 to March 2017. Patients with relapsing-remitting multiple sclerosis on DMT for ≥ 3 months and ≤ 2 years (per local labelling) from 10 multiple sclerosis centers across Slovakia were included. The primary objective was to collect the Treatment Satisfaction Questionnaire for Medication version 9 (TSQM 9) score regarding perceived effectiveness, convenience and overall satisfaction with DMT.
Results: The following TSQM 9 scores (mean; 95% confidence interval) were reported from 415 patients: convenience (75.05; 73.49– 76.61), effectiveness (68.15; 66.56– 69.75) and global satisfaction scale (66.94; 65.26– 68.62). All three parameters of the TSQM 9 were analyzed by the route of DMT administration, with infusions best rated for effectiveness and global satisfaction in comparison to oral dosage and injections. For convenience, however, oral dosage forms were appraised highly (82.66; 80.59– 84.73) followed by infusions (74.40; 70.12– 78.69), while injections were rated as the worst (66.92; 64.81– 69.04). The difference of TSQM 9 scores according to the route of DMT administration is statistically significant for convenience (p < 0.001) and global satisfaction (p = 0.004), but not for effectiveness (p = 0.185).
Conclusion: In the present study, it was confirmed that patients find oral DMTs as most convenient; however, the infusion form of treatment outweighs oral DMTs in global satisfaction and effectiveness. The differences of TSQM 9 scores among DMT dosage forms were significant for convenience and global satisfaction. In conclusion, the results of this detailed survey increase our understanding of RRMS patient population characteristics and patient satisfaction with DMT treatment.

Keywords: multiple sclerosis, disease-modifying therapy, treatment satisfaction, treatment pattern, real-world

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