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Rare complications of neurofibromatosis 1 diagnosed incidentally in two children

Authors Lazea C, Asavoaie C, Al-Khzouz C, Popa L

Received 15 May 2018

Accepted for publication 13 June 2018

Published 31 August 2018 Volume 2018:14 Pages 1547—1552


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh

Cecilia Lazea,1 Carmen Asavoaie,2 Camelia Al-Khzouz,3 Lenuta Popa1

1Department of Pediatrics I, Emergency Clinic Hospital for Children, “Iuliu Hatieganu” University of Medicine and Pharmacy, 2Department of Imaging and Radiology, Emergency Clinic Hospital for Children, 3Medical Genetics Department, Emergency Clinic Hospital for Children, University of Medicine and Pharmacy, Cluj-Napoca, Romania

Abstract: Neurofibromatosis 1 (NF1) is an autosomal-dominant disorder with various clinical expressivity and complications. Arterial hypertension may be present in patients with NF1 and is secondary to vasculopathy or pheochromocytoma. We herein describe two children (17 and 4 years old) diagnosed late with NF1 after severe arterial hypertension had been discovered due to pheochromocytoma and middle aortic syndrome. Routine measurement of arterial pressure is mandatory in children with NF1, in order to diagnose the complications of this disease.

Keywords: neurofibromatosis, pheochromocytoma, middle aortic syndrome, arterial hypertension, children

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