Back to Journals » Therapeutics and Clinical Risk Management » Volume 14

Rare complications of neurofibromatosis 1 diagnosed incidentally in two children

Authors Lazea C, Asavoaie C, Al-Khzouz C, Popa L

Received 15 May 2018

Accepted for publication 13 June 2018

Published 31 August 2018 Volume 2018:14 Pages 1547—1552

DOI https://doi.org/10.2147/TCRM.S173237

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Cristina Weinberg

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh


Cecilia Lazea,1 Carmen Asavoaie,2 Camelia Al-Khzouz,3 Lenuta Popa1

1Department of Pediatrics I, Emergency Clinic Hospital for Children, “Iuliu Hatieganu” University of Medicine and Pharmacy, 2Department of Imaging and Radiology, Emergency Clinic Hospital for Children, 3Medical Genetics Department, Emergency Clinic Hospital for Children, University of Medicine and Pharmacy, Cluj-Napoca, Romania

Abstract: Neurofibromatosis 1 (NF1) is an autosomal-dominant disorder with various clinical expressivity and complications. Arterial hypertension may be present in patients with NF1 and is secondary to vasculopathy or pheochromocytoma. We herein describe two children (17 and 4 years old) diagnosed late with NF1 after severe arterial hypertension had been discovered due to pheochromocytoma and middle aortic syndrome. Routine measurement of arterial pressure is mandatory in children with NF1, in order to diagnose the complications of this disease.

Keywords: neurofibromatosis, pheochromocytoma, middle aortic syndrome, arterial hypertension, children

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]