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Radiation-induced esophagitis in lung cancer

Authors Baker S, Fairchild A

Received 31 May 2016

Accepted for publication 22 July 2016

Published 13 October 2016 Volume 2016:7 Pages 119—127

DOI https://doi.org/10.2147/LCTT.S96443

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Pan-Chyr Yang

Sarah Baker, Alysa Fairchild

Department of Radiation Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, Canada

Abstract: Radiation-induced esophagitis is the most common local acute toxicity of radiotherapy (RT) delivered for the curative or palliative intent treatment of lung cancer. Although concurrent chemotherapy and higher RT dose are associated with increased esophagitis risk, advancements in RT techniques as well as adherence to esophageal dosimetric constraints may reduce the incidence and severity. Mild acute esophagitis symptoms are generally self-limited, and supportive management options include analgesics, acid suppression, diet modification, treatment for candidiasis, and maintenance of adequate nutrition. Esophageal stricture is the most common late sequela from esophageal irradiation and can be addressed with endoscopic dilatation. Approaches to prevent or mitigate these toxicities are also discussed.

Keywords: non–small cell lung cancer, acute, late, toxicity, stricture

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