Dr Xie Maohua
Consulting Editor: Maohua Xie (PhD)
Dr. Maohua Xie received his Ph.D. degree in Molecular Biology and Biochemistry at Wuhan University of China in 2008. He was trained as postdoctoral fellow in Dr. Xingming Deng's laboratory at the Winship Cancer Institute of Emory University before he was promoted to Research Associate in 2014. Dr. Xie has extensive publications in major peer-reviewed journals such as Nature Communications, Cancer Research, Nucleic Acid Research, Cell Death and Differentiation, Journal of Bacteriology and Molecular Cancer Therapy.
His research interests are focused on:
(1) Developing new agents and strategies for treatment of lung cancers by targeting the components of apoptosis or DNA repair signaling pathways.
(2) Uncovering the role of Bcl-2 family proteins in regulating DNA repair and DNA replication stress signaling pathways.
His research affects cancer diagnosis and treatment because understanding of the molecular basis of tumorigenesis and developing novel anti-cancer drugs will provide valuable insight to improve therapeutic strategy and outcome of cancer treatment. Among his top research accomplishments is identifiying three small-molecule Bax activators that target the S184 site of Bax, which could activate the cell death machineries of Bax and potently repress lung tumor growth.