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Psychotropic drug therapy in patients in the intensive care unit - usage, adverse effects and drug interactions: a review

Authors Shafiekhani M, Mirjalili M, Vazin A

Received 1 June 2018

Accepted for publication 2 August 2018

Published 28 September 2018 Volume 2018:14 Pages 1799—1812

DOI https://doi.org/10.2147/TCRM.S176079

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Professor Garry Walsh


Mojtaba Shafiekhani, Mahtabalsadat Mirjalili, Afsaneh Vazin

Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract: Managing psychological problems in patients admitted to intensive care unit (ICU) is a big challenge, requiring pharmacological interventions. On the other hand, these patients are more prone to side effects and drug interactions associated with psychotropic drugs use. Benzodiazepines (BZDs), antidepressants, and antipsychotics are commonly used in critically ill patients. Therefore, their therapeutic effects and adverse events are discussed in this study. Different studies have shown that non-BZD drugs are preferred to BZDs for agitation and pain management, but antipsychotic agents are not recommended. Also, it is better not to start antidepressants until the patient has fully recovered. However, further investigations are required for the use of psychotropic drugs in ICUs.

Keywords:
critical care, delirium, sedation, antipsychotics, benzodiazepines

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