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Prognostic value of TIGAR and LC3B protein expression in nasopharyngeal carcinoma

Authors Wei M, Peng J, Wu P, Chen P, Yang H, Cui Y, Yang L

Received 27 May 2018

Accepted for publication 30 August 2018

Published 12 November 2018 Volume 2018:10 Pages 5605—5616

DOI https://doi.org/10.2147/CMAR.S175501

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 4

Editor who approved publication: Professor Nakshatri


Min Wei,* Jinxia Peng,* Peng Wu, Ping Chen, Hongru Yang, Yongxia Cui, Linglin Yang

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, People’s Republic of China

*These authors contributed equally to this work

Purpose: Autophagy, the process responsible for degrading cytoplasmic organelles to sustain cellular metabolism, has been associated with cancer initiation and progression. As TP53-induced glycolysis and apoptosis regulator (TIGAR) is among the important genes that can regulate autophagy, we aimed to investigate the correlation between the expression levels of TIGAR and the autophagy-related protein microtubule-associated protein 1 light chain 3 (LC3B), as well as their association with clinical outcomes, in nasopharyngeal carcinoma (NPC) patients.
Methods: We detected the expressions of TIGAR and LC3B in 182 NPC tissue samples via immunohistochemical staining.
Results: A significant correlation between TIGAR and LC3B expressions was identified (P=0.045). Moreover, survival analysis showed that TIGAR– or LC3B+ expression was associated with improved overall survival, local regional failure-free survival, distant failure-free survival, and failure-free survival rates, compared with TIGAR+ or LC3B– expression, respectively. Meanwhile, when combining TIGAR with LC3B expression in terms of prognostic value, patients with TIGAR+/LC3B– expression were significantly disadvantaged with regard to overall survival, local regional failure-free survival , distant failure-free survival, and failure-free survival compared with other groups based on the log-rank test and Cox regression analyses (all P<0.05).
Conclusion: TIGAR and LC3B may be novel biomarkers for predicting the prognosis of NPC patients and could be utilized as potential targets for future therapeutics aimed at treating NPC patients.

Keywords: nasopharyngeal carcinoma, TIGAR, LC3B, autophagy, prognosis

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