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Profound thrombocytopenia after primary exposure to eptifibatide

Authors Norgard N, Badgley B

Published 21 September 2010 Volume 2010:2 Pages 163—167


Review by Single anonymous peer review

Peer reviewer comments 4

Nicholas B Norgard, Brian T Badgley
University at Buffalo, School of Pharmacy and Pharmaceutical Sciences, Buffalo, NY, USA

Abstract: Eptifibatide is a glycoprotein IIb/IIIa receptor antagonist used to reduce the incidence of ischemic events in patients with acute coronary syndromes and those undergoing percutaneous coronary intervention. A minority of patients given eptifibatide develop acute, profound thrombocytopenia (<20,000 cells/mm3) within a few hours of receiving the drug. This case report discusses a patient who developed profound thrombocytopenia within hours of receiving eptifibatide for the first time. The Naranjo algorithm classified the likelihood that this patient’s thrombocytopenia was related to eptifibatide as probable. Profound thrombocytopenia is an uncommon but clinically important complication of eptifibatide. This case report emphasizes the importance of monitoring platelet counts routinely at baseline and within 2–6 hours of eptifibatide administration.

Keywords: drug-induced thrombocytopenia, glycoprotein IIb/IIIa antagonists, eptifibatide, thrombocytopenia

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