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Processing and storage of blood components: strategies to improve patient safety

Authors Pietersz R, van der Meer P

Received 7 May 2015

Accepted for publication 18 June 2015

Published 11 August 2015 Volume 2015:3 Pages 55—64

DOI https://doi.org/10.2147/IJCTM.S40038

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Cees Th. Smit Sibinga


Ruby NI Pietersz, Pieter F van der Meer

Department of Product and Process Development, Sanquin Blood Bank, Amsterdam, the Netherlands

Abstract: This review focuses on safety improvements of blood processing of various blood components and their respective storage. A solid quality system to ensure safe and effective blood components that are traceable from a donor to the patient is the foundation of a safe blood supply. To stimulate and guide this process, National Health Authorities should develop guidelines for blood transfusion, including establishment of a quality system. Blood component therapy enabled treatment of patients with blood constituents that were missing, only thus preventing reactions to unnecessarily transfused elements. Leukoreduction prevents many adverse reactions and also improves the quality of the blood components during storage. The safety of red cells and platelets is improved by replacement of plasma with preservative solutions, which results in the reduction of isoantibodies and plasma proteins. Automation of blood collection, separation of whole blood into components, and consecutive processing steps, such as preparation of platelet concentrate from multiple donations, improves the consistent composition of blood components. Physicians can better prescribe the number of transfusions and therewith reduce donor exposure and/or the risk of pathogen transmission. Pathogen reduction in cellular blood components is the latest development in improving the safety of blood transfusions for patients.

Keywords: blood components, red cell concentrates, platelet concentrates, plasma, transfusion, safety
 

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