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Primary primitive neuroectodermal tumor of the cervix

Authors Li B, Ouyang L, Han X, Zhou Y, Xin Tong, Zhang Z, Zhang Z, han Y, Qiu X

Received 28 March 2013

Accepted for publication 7 May 2013

Published 17 June 2013 Volume 2013:6 Pages 707—711


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 4

Bo Li,1 Ling Ouyang,1 Xue Han,1 Yang Zhou,1 Xin Tong,1 Shulang Zhang,1 Qingfu Zhang2

1Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, 2Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, People’s Republic of China

Abstract: Primary primitive neuroectodermal tumors (PNETs) are rare and high-grade malignant tumors that mostly occur in children and young adults. The most common sites are the trunk, limbs, and retroperitoneum. Herein, we present a case of a PNET involving the cervix uteri in a 27-year-old woman. The lesion showed characteristic histologic features of a PNET and was positive for the immunohistochemical markers cluster of differentiation (CD) 99, vimentin, neuron-specific enolase, neural cell adhesion molecule 1 (CD56), and CD117 (c-kit), further defining the tumor while helping to confirm PNET. The clinical Stage IIIB tumor was treated with chemotherapy and radiotherapy.

Keywords: primitive neuroectodermal tumor, PNET, cervical neoplasm, immunohistochemistry

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