Back to Journals » International Journal of Women's Health » Volume 4

Prevalence and risk factors for cervical squamous intraepithelial lesions among women infected with HIV-1 in Makurdi, Nigeria

Authors Swende T, Ngwan S, Swende

Received 9 April 2011

Accepted for publication 25 November 2011

Published 14 February 2012 Volume 2012:4 Pages 55—60

DOI https://doi.org/10.2147/IJWH.S21205

Review by Single anonymous peer review

Peer reviewer comments 3


Terrumun Z Swende1,2, Stephen D Ngwan2, Laadi T Swende3

1Department of Obstetrics and Gynecology, College of Health Sciences, Benue State University, Makurdi, 2Department of Obstetrics and Gynecology, 3Department of Family Medicine, Federal Medical Center Makurdi, Makurdi, Nigeria

Background: The purpose of this study was to determine the prevalence and risk factors for cervical squamous intraepithelial lesions (SIL) among women infected with human immunodeficiency virus type 1 (HIV-1) receiving care at the Federal Medical Center Makurdi, Nigeria.
Methods: Between March and December 2009, a total of 253 women infected with HIV-1 had cervical smears taken for cytology. HIV-1 RNA viral load and CD4 counts were also measured.
Results: Of the 253 women, cervical SIL were present in 45 (17.8%). However, abnormal cervical cytology was noted in 146 (57.7%). Of those with abnormal cervical cytology, 101 (39.9%) women had atypical squamous cells of undetermined significance, 16 (6.3%) had low-grade SIL, and 29 (11.5%) women had high-grade SIL. The median CD4 lymphocyte count was lower in participants with cervical SIL compared with those without (132 versus 184 cells/mm3; P = 0.03). The median HIV-1 RNA viral load was higher in women with cervical SIL (102,705 versus 64,391 copies/mL; P = 0.02). A CD4 lymphocyte count of <200 cells/mm3 and an HIV-1 RNA viral load of <10,000 copies/mL were found to be significantly associated with cervical SIL.
Conclusion: A high prevalence of cervical SIL was found among HIV-1-infected women in Makurdi, Nigeria. Increased immune suppression and HIV-1 viremia are significantly associated with cervical SIL.

Keywords: cervical squamous intraepithelial lesions, human immunodeficiency virus, risk factors, immunosuppression, cervical dysplasia, Nigeria

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]