Premature ovarian failure risk factors in an Iranian population
Alieh Ghassemzadeh1,2, Laya Farzadi1,2, Elaheh Beyhaghi1,2
1Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 2Alzahra University Hospital, Department of Obstetrics and Gynecology, Tabriz University of Medical Sciences, Tabriz, Iran
Background: The aim of this study was to determine possible correlates of premature ovarian failure (POF) in an Iranian population.
Methods: In a case-control study, 80 patients with POF were compared with 80 controls enrolled from the same setting during 2007–2008. A food diary was used to assess food consumption habits.
Results: Mean age of starting ovarian failure symptoms was 19.3 ± 5.7 years and mean age of menopause was 22.6 ± 6.3 years. Familial coincidence was observed in 16 POF patients versus no one in the control group (P < 0.05). POF patients had lower frequency of both eating red meat and fish when compared with controls (P < 0.001). POF and control subjects consumed similar amounts of dairy products, being 5.3 ± 3.2 times per week in POF and 5.6 ± 2.1 times in the control groups.
Conclusion: In this study, an association between POF and lower red meat or fish consumption was found.
Keywords: POF, etiology, case-control, nutrition, premature menopause, premature ovarian dysfunction, primary ovarian insufficiency
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