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Prefilled syringes and usability of ophthalmic viscosurgical devices

Authors Shiba T, Tsuneoka H

Received 13 May 2014

Accepted for publication 9 June 2014

Published 4 September 2014 Volume 2014:8 Pages 1697—1702

DOI https://doi.org/10.2147/OPTH.S67689

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3


Takuya Shiba, Hiroshi Tsuneoka

Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan

Purpose: To examine the influence of the configuration of prefilled syringes on the usability of ophthalmic viscosurgical devices (OVDs).
Setting: Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan.
Design: Experimental study.
Methods: The maximum force needed to extrude the whole OVD (extrusion force) was compared among viscous cohesive OVDs (OPEGAN Hi® 0.85 mL and Healon® 0.85 mL) and very low viscosity dispersive OVDs (OPEGAN® 0.6 mL and OPEGAN® 1.1 mL). Additionally, to exclude the influence of any differences between syringes of viscous cohesive OVDs on the extrusion force, empty syringes of the same configuration were refilled with the same products. In addition, the syringe inner surface and that of the piston attached to the tip of the plunger were measured.
Results: The extrusion force of Healon 0.85 mL (3.28±0.19 kgf) was significantly (P<0.01) higher than that of OPEGAN Hi 0.85 mL (2.54±0.23 kgf). The inner syringe chamber for Healon 0.85 mL was vial shaped and had a built-in needle in the Luer tip, which was clearly different from OPEGAN Hi 0.85 mL. There were no significant differences in the extrusion force between refilled syringes. The extrusion force of OPEGAN 1.1 mL (3.44±0.12 kgf) was significantly (P<0.01) higher than that of OPEGAN 0.6 mL (1.63±0.06 kgf). The syringe of OPEGAN 1.1 mL was obviously bigger than that of OPEGAN 0.6 mL.
Conclusion: It was confirmed that the configuration of the syringes is another determinant of the extrusion force and a factor related to the difference in usability among products that meet the same cohesive class.

Keywords: configuration, syringe, extrusion force, viscous cohesive OVDs, low viscosity dispersive OVDs

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