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Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Authors Qing Y, Cheng L, Li R, Liu G, Zhang Y, Tang X, Wang J, Liu H, Qin Y

Received 9 February 2018

Accepted for publication 9 April 2018

Published 5 June 2018 Volume 2018:13 Pages 3311—3327

DOI https://doi.org/10.2147/IJN.S165125

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Alexander Kharlamov

Peer reviewer comments 3

Editor who approved publication: Dr Linlin Sun


Yun’an Qing,1 Lin Cheng,2 Ruiyan Li,1 Guancong Liu,1 Yanbo Zhang,1 Xiongfeng Tang,1 Jincheng Wang,1 He Liu,1 Yanguo Qin1

1Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China; 2Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China

Abstract: Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a reasonable manner, it is critical for us to know the specific antibacterial mechanism, which is still unclear. In this review, we analyzed the potential antibacterial mechanisms of AgNPs, and the influences of AgNPs on osteogenic-related cells, including cellular adhesion, proliferation, and differentiation, were also discussed. In addition, methods to enhance biocompatibility of AgNPs as well as advanced implants modifications technologies were also summarized.

Keywords: antibacterial mechanism, biocompatibility, osteogenic-related cells, orthopedic implants, silver nanoparticles, surface modification

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