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Platelet-rich plasma for the treatment of chronic wounds: evidence to date

Authors Conde-Montero E, de la Cueva Dobao P, Martínez González JM

Received 27 March 2017

Accepted for publication 21 June 2017

Published 4 September 2017 Volume 2017:4 Pages 107—120

DOI https://doi.org/10.2147/CWCMR.S118655

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 2

Editor who approved publication: Professor Marco Romanelli


Elena Conde-Montero,1 Pablo de la Cueva Dobao,1 José María Martínez González2

1Department of Dermatology, Hospital Universitario Infanta Leonor, 2Faculty of Dentistry, Universidad Complutense de Madrid, Madrid, Spain

Abstract: Platelet-rich plasma (PRP) is a widely used throughout diverse fields of medicine for improving tissue regeneration. In dermatology, its main applications in the last few years have mainly been in antiaging treatment and wound healing. PRP contains platelets at higher concentrations than whole blood, and consequently represents a growth-factor pool. Chronic wounds are characterized by a prolonged inflammatory phase, involving a continuous destruction of matrix proteins and growth factors. Growth factors promote cell migration, proliferation, and differentiation, which are essential for wound healing. In this review, we explain the basic principles of PRP in wound healing and aim to offer an updated critical assessment of the available clinical evidence that supports the utility of PRP for the therapeutic challenge that chronic ulcers represent in our daily clinical practice.

Keywords: platelet-rich plasma, chronic wounds, growth factors, wound healing, platelet gel

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