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Photodynamic therapy of tumors with pyropheophorbide-a-loaded polyethylene glycol–poly(lactic-co-glycolic acid) nanoparticles

Authors Liu H, Zhao M, Wang J, Pang M, Wu Z, Zhao L, Yin Z, Hong Z

Received 11 May 2016

Accepted for publication 17 August 2016

Published 27 September 2016 Volume 2016:11 Pages 4905—4918


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Lei Yang

Hui Liu,1 Mei Zhao,1 Jin Wang,1 Mingpei Pang,1 Zhenzhou Wu,1 Liqing Zhao,1 Zhinan Yin,1,2 Zhangyong Hong1

1State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, 2Biomedical Translational Research Institute, International Immunology Center, Jinan University, Guangzhou, People’s Republic of China

Abstract: Photodynamic therapy (PDT) has many advantages in treating cancers, but the lack of ideal photosensitizers continues to be a major limitation restricting the clinical utility of PDT. This study aimed to overcome this obstacle by generating pyropheophorbide-a-loaded polyethylene glycol–poly(lactic-co-glycolic acid) nanoparticles (NPs) for efficient tumor-targeted PDT. The fabricated NPs were efficiently internalized in the mitochondrion by cancer cells, and they efficiently killed cancer cells in a dose-dependent manner when activated with light. Systemically delivered NPs were highly enriched in tumor sites, and completely ablated the tumors in a xenograft KB tumor mouse model when illuminated with 680 nm light (156 mW/cm2, 10 minutes). The results suggested that this tumor-specific NP-delivery system for pyropheophorbide-a has the potential to be used in tumor-targeted PDT.

Keywords: photodynamic therapy, photosensitizer, pyropheophorbide-a, nanoparticle

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