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Pharmacotherapeutic considerations for chronic pain in chronic kidney and end-stage renal disease

Authors Mathew RO, Bettinger JJ, Wegrzyn EL, Fudin J 

Received 20 October 2016

Accepted for publication 28 October 2016

Published 8 December 2016 Volume 2016:9 Pages 1191—1195

DOI https://doi.org/10.2147/JPR.S125270

Checked for plagiarism Yes

Editor who approved publication: Dr Michael Schatman

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Roy O Mathew,1 Jeffrey J Bettinger,2 Erica L Wegrzyn,3 Jeffrey Fudin3,4

1Department of Medicine, Wm. Jennings Bryan Dorn VA Medical Center, Columbia, SC, 2Department of Professional Practice, Albany College of Pharmacy and Health Sciences, 3Department of Pharmacy, Albany Stratton VA Medical Center, Albany, 4Scientific and Clinical Affairs, Remitigate, LLC, Delmar, NY, USA

In hemodialysis (HD) patients, the prevalence of chronic pain can be up to 92%.1 A survey of HD patients found 55% reported a severe pain episode in the previous 24 hours.2 Furthermore, ~75% of HD patients report inadequate pain management.2 Despite these shocking statistics there is no universally accepted guideline for the treatment of pain in HD patients. Nevertheless, poorly managed pain in HD patients promulgates psychological disturbances, impaired sleep, decreased dialysis compliance, and an overall decline in quality of life.1

Disclosure

Jeffrey Fudin is associated with the following: Astra Zeneca (Speakers Bureau, Advisory Board), Clarity (Consultant), DepoMed (Advisory Board, Speakers Bureau), Endo (Consultant, Speakers Bureau), Kaléo (Speakers Bureau, Advisory Board), Kashiv Pharma (Advisory Board), KemPharm (Consultant), Pernix Therapeutics (Speaker), Remitigate, LLC (Owner), and Scilex Pharmaceuticals (Consultant). This article is the sole work of the authors, and stated opinions/assertions do not reflect the opinion of employers, employee affiliates, and/or pharmaceutical companies listed. It was not prepared as part of the authors’ duty as federal employees. The authors report no other conflicts of interest in this work.

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