Pharmacotherapeutic considerations for chronic pain in chronic kidney and end-stage renal disease
Roy O Mathew,1 Jeffrey J Bettinger,2 Erica L Wegrzyn,3 Jeffrey Fudin3,4
1Department of Medicine, Wm. Jennings Bryan Dorn VA Medical Center, Columbia, SC, 2Department of Professional Practice, Albany College of Pharmacy and Health Sciences, 3Department of Pharmacy, Albany Stratton VA Medical Center, Albany, 4Scientific and Clinical Affairs, Remitigate, LLC, Delmar, NY, USA
In hemodialysis (HD) patients, the prevalence of chronic pain can be up to 92%.1 A survey of HD patients found 55% reported a severe pain episode in the previous 24 hours.2 Furthermore, ~75% of HD patients report inadequate pain management.2 Despite these shocking statistics there is no universally accepted guideline for the treatment of pain in HD patients. Nevertheless, poorly managed pain in HD patients promulgates psychological disturbances, impaired sleep, decreased dialysis compliance, and an overall decline in quality of life.1
Jeffrey Fudin is associated with the following: Astra Zeneca (Speakers Bureau, Advisory Board), Clarity (Consultant), DepoMed (Advisory Board, Speakers Bureau), Endo (Consultant, Speakers Bureau), Kaléo (Speakers Bureau, Advisory Board), Kashiv Pharma (Advisory Board), KemPharm (Consultant), Pernix Therapeutics (Speaker), Remitigate, LLC (Owner), and Scilex Pharmaceuticals (Consultant). This article is the sole work of the authors, and stated opinions/assertions do not reflect the opinion of employers, employee affiliates, and/or pharmaceutical companies listed. It was not prepared as part of the authors’ duty as federal employees. The authors report no other conflicts of interest in this work.
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