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Pharmacogenomic testing: aiding in the management of psychotropic therapy for adolescents with autism spectrum disorders

Authors Bose-Brill S, Xing J, Barnette DJ, Hanks C

Received 15 December 2016

Accepted for publication 26 April 2017

Published 25 September 2017 Volume 2017:10 Pages 247—252

DOI https://doi.org/10.2147/PGPM.S130247

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 4

Editor who approved publication: Dr Martin Bluth


Seuli Bose-Brill,1 Jinming Xing,2 Debra J Barnette,1,2 Christopher Hanks1

1Internal Medicine and Pediatrics at Grandview, Wexner Medical Center, 2Department of Practice and Science, College of Pharmacy, The Ohio State University, Columbus, OH, USA

Abstract: Adolescents with autism have higher rates of anxiety than the general adolescent population. They often struggle to express psychological symptoms verbally where their symptoms may manifest as withdrawal and agitation. Adolescent patients with autism have higher rates of polypharmacy and high-risk psychiatric medication use (eg, atypical antipsychotics) than other patients with psychiatric illness. Primary care pediatricians are at the front lines of psychiatric management for patients with autism. Yet, they have inadequate access to pediatric psychiatry for complex medication management. Pharmacogenomic testing can provide personalized drug metabolism profiles for a majority of psychotropic medications. Primary care based pharmacogenomic testing for adolescents with autism on one or more psychiatric medications may help individualize and optimize complex medication regimens, while promoting drug safety.

Keywords: autism, pharmacogenomic, pharmacogenetic, pharmacotherapy, anxiety, depression, psychiatry, pediatrics

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