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Pharmacogenetics of alcohol addiction: current perspectives

Authors Zastrozhin MS, Skryabin VY, Miroshkin SS, Bryun EA, Sychev DA

Received 25 February 2019

Accepted for publication 10 June 2019

Published 11 July 2019 Volume 2019:12 Pages 131—140

DOI https://doi.org/10.2147/TACG.S206745

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 4

Editor who approved publication: Prof. Dr. Martin H. Maurer


M S Zastrozhin,1,2 V Yu Skryabin,1 S S Miroshkin,1,2 E A Bryun,1,2 D A Sychev1,2

1Moscow Research and Practical Centre on Addictions of the Moscow Department of Healthcare, Moscow 109390, Russian Federation; 2Department of Addictology, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian Federation, Moscow 123995, Russian Federation

Abstract: Genetics of alcohol addiction is currently a contradictive and complex field, where data in the most studies reflect methods’ limitations rather than meaningful and complementary results. In our review, we focus on the genetics of alcohol addiction, leaving genetics of acute alcohol intoxication out of the scope. A review of the literature on pharmacogenetic biomarkers development for the pharmacotherapy personalization reveals that today the evidence base concerning these biomarkers is still insufficient. In particular, now the researches with the design of randomized controlled trials and meta-analysis investigating the effect of the SNPs as biomarkers on the therapy efficacy are available for naltrexone only. For other medications, there are only a few studies in small samples. It decreases the possibilities to implement the pharmacogenetic algorithms for the pharmacotherapy personalization in patients with alcohol use disorders (AUD). In view of the importance of the precision approaches development not in addiction medicine only, but in other fields of medicine also to increase the efficacy and safety of the therapy, studies on pharmacogenetic biomarkers development for the medications used in patients with AUD (eg, naltrexone, disulfiram, nalmefene, acamprosate, etc.) remain relevant to this day.

Keywords: pharmacogenetics, pharmacogenomics, alcohol use disorder, naltrexone, acamprosate, nalmefene

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