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Peripheral hypertrophic subepithelial corneal degeneration: clinical aspects related to in vivo confocal microscopy and optical coherence tomography

Authors Gunzinger JM, Voulgari N, Petrovic A, Hashemi K, Kymionis G

Received 11 March 2019

Accepted for publication 24 June 2019

Published 26 July 2019 Volume 2019:12 Pages 237—241


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Jeanne Martine Gunzinger, Nafsika Voulgari, Aleksandra Petrovic, Kattayoon Hashemi, Georgios Kymionis

Lausanne University, Cornea and Refractive Surgery Department, Jules-Gonin Eye Hospital, Lausanne, Switzerland

Purpose: To report the findings of anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscopy (IVCM) in two patients with peripheral hypertrophic subepithelial corneal degeneration (PHSD).
Methods: Case series by retrospective chart review and imaging analysis of AS-OCT and IVCM.
Results: Slit lamp examination of the two patients revealed a bilateral subepithelial-elevated fibrous tissue of the superior-nasal quadrant, as well as inferior-nasal in one of the patients. Best corrected visual acuity ranged from 20/25 to 20/15. AS-OCT showed continuous, homogenous, well-demarked hyperreflective subepithelial band associated with hyperreflectivity in the anterior stroma. IVCM demonstrated normal epithelial cell morphology and arrangement and a fibrous structure subepithelial and in the anterior stroma.
Conclusion: AS-OCT and IVCM can facilitate the diagnosis of PHSD and differentiate it from other corneal entities that present peripheral opacifications.

Keywords: peripheral hypertrophic subepithelial corneal degeneration, anterior segment optical coherence tomography, in vivo confocal microscopy, peripheral corneal opacification

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