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Pediatric anaphylaxis and hyper IgE syndrome

Authors Dosanjh A

Received 1 December 2016

Accepted for publication 27 January 2017

Published 28 February 2017 Volume 2017:10 Pages 31—33

DOI https://doi.org/10.2147/JAA.S129160

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 3

Editor who approved publication: Dr Luis Garcia-Marcos

Amrita Dosanjh

Department of Pediatrics, Rady Childrens Hospital, San Diego, CA, USA

Abstract: Patients with autosomal-dominant (AD) hyper immunoglobulin E (IgE) syndrome (HIES) or Job syndrome develop frequent dermatologic and pulmonary infections. As patients have an extreme elevation of IgE levels, this database analysis study sought to study the association between AD HIES, Job syndrome, and anaphylaxis. HIES is a heterogeneous group of immune disorders characterized by extremely elevated levels of serum IgE. Although the molecular defects and clinical phenotypes found in association with Job syndrome are well characterized, the association with severe allergic reactions and anaphylaxis is a subject of ongoing investigation.

Keywords:
anaphylaxis, hyper IgE syndrome, allergy, pediatrics
 

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