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Patients with cervical intraepithelial neoplasms show different states of health-related quality of life and different coping styles depending on the choice of therapy: findings from the CIN study

Authors Klügel S, Lücke C, Mehren A, Malik E, Philipsen A, Schild-Suhren M, Müller HHO

Received 11 March 2019

Accepted for publication 23 July 2019

Published 12 September 2019 Volume 2019:11 Pages 511—517

DOI https://doi.org/10.2147/IJWH.S208257

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Everett Magann


Stephanie Klügel,1 Caroline Lücke,2 Aylin Mehren,1,3 Eduard Malik,4 Alexandra Philipsen,2 Meike Schild-Suhren,4,* Helge HO Müller1,2,*

1Department of Psychiatry and Psychotherapy, Carl von Ossietzky University Oldenburg, Oldenburg, Germany; 2Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany; 3Biological Psychology Lab, Department of Psychology, Carl von Ossietzky University Oldenburg, Oldenburg, Germany; 4Department of Gynecology and Obstetrics, Carl Von Ossietzky University Oldenburg, Oldenburg, Germany

*These authors contributed equally to this work

Correspondence: Stephanie Klügel; Helge HO Müller
Department of Psychiatry and Psychotherapy, Carl von Ossietzky University Oldenburg, Oldenburg, Germany
Tel +49 171 799 0959
Email stephanie.kluegel@gmx.de; helge.mueller@ukbonn.de

Purpose: To examine the effects of type of therapy (conservative therapy vs conization) on the psychosocial well-being of patients with cervical intraepithelial neoplasia grade II (CIN II) in a prospective cross-sectional study designed to simplify future choice of therapy.
Patients and methods: In a cross-sectional study comparing 24 CIN II patients who were treated via conservative therapy with 17 CIN II patients who were treated via conization (not randomized), we examined the association between therapy type and psychosocial well-being after the treatment. Scores on the Hospital Anxiety and Depression Scale (HADS) (prevalence of depression/anxiety), SF-12 (health-related quality of life (HRQoL)) and Brief COPE (coping mechanisms) questionnaires were compared between the two subgroups via nonparametric Mann-Whitney U-tests.
Results: The prevalence of depression/anxiety and mental HRQoL did not differ between patients undergoing conservative therapy and those undergoing conization but differed significantly from those of the healthy population. Regarding physical HRQoL and coping strategies, the conservative therapy subgroup achieved higher scores and better performance.
Conclusion: Patients with CIN II are at risk of developing depressive or anxiety symptoms. The choice of therapy seems to have an influence on physical HRQoL and coping strategies but not on depression/anxiety and mental HRQoL.

Keywords: cervical cancer, coping styles, health-related quality of life

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