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Patient selection for corneal collagen cross-linking: an updated review

Authors Galvis V, Tello A, Ortiz AI, Escaf LC

Received 4 January 2017

Accepted for publication 7 March 2017

Published 7 April 2017 Volume 2017:11 Pages 657—668

DOI https://doi.org/10.2147/OPTH.S101386

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Virgilio Galvis,1–3 Alejandro Tello,1–3 Alvaro I Ortiz,3 Luis C Escaf2

1Centro Oftalmológico Virgilio Galvis, Floridablanca, 2Department of Ophthalmology, Faculty of Health Sciences, Universidad Autónoma de Bucaramanga, Bucaramanga, 3Department of Ophthalmology, Fundación Oftalmológica de Santander (FOSCAL), Floridablanca, Santander, Colombia

Abstract: Corneal cross-linking (CXL) is an option that in the last decade has demonstrated its efficacy and safety in halting the progression of keratoconus (KCN) and other corneal ectasias. Its indication has been extended beyond the classic definition that required evidence of KCN progression, especially in the presence of some risk factors for a possible progression (particularly the younger age). However, the results can be still somewhat variable today. There are several protocols, each with its own advantages and disadvantages. Some predictors of CXL outcome have been identified. We will review the current knowledge on patient selection for CXL, its indications, and options in special cases (such as thin corneas).

Keywords: keratoconus, cornea, cross-linking, corneal collagen cross-linking, keratoectasia

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