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Papilloma and sebaceous gland hyperplasia of the lacrimal caruncle: a case report

Authors Miura-Karasawa M, Toshida H, Ohta T, Murakami A

Received 14 January 2018

Accepted for publication 6 March 2018

Published 27 April 2018 Volume 2018:11 Pages 91—95

DOI https://doi.org/10.2147/IMCRJ.S162528

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Dr Scott Fraser

Maria Miura-Karasawa,1 Hiroshi Toshida,1 Toshihiko Ohta,1 Akira Murakami2

1Department of Ophthalmology, Juntendo University Shizuoka Hospital, Izunokuni, Shizuoka, Japan; 2Department of Ophthalmology, Juntendo University School of Medicine, Tokyo, Japan

Objective: To report a case of coincidence of sebaceous gland hyperplasia and papilloma with detection of human papillomavirus-51 in the apical portion by in situ hybridization.
Case presentation: A 75-year-old man noted discomfort at the inner canthus of his left eye when he blinked. A tumor of the lacrimal caruncle was identified and resected. The base of the tumor had a smooth surface and was whitish. In addition, a “navel-like structure” was seen, and the findings strongly suggested sebaceous gland hyperplasia of the lacrimal caruncle. The apical portion of the tumor was a papillomatous lesion. Histological examination of the resected tumor led to a diagnosis of sebaceous gland hyperplasia. Human papillomavirus-51 was detected in the apical portion by in situ hybridization. Based on these results, the final diagnosis was sebaceous gland hyperplasia with papilloma. No recurrence of either tumor has been observed up to 3 years postoperatively.
Conclusion: This might be the first report of a case of coincidence of sebaceous gland hyperplasia and papilloma, even though the association between these two lesions was unclear, including which developed first.

Keywords: lacrimal caruncle, sebaceous gland hyperplasia, papilloma, human papilloma virus, HPV-51

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