Back to Browse Journals » Vascular Health and Risk Management » Volume 10

Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation

Authors Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T

Received 6 November 2013

Accepted for publication 30 December 2013

Published 27 February 2014 Volume 2014:10 Pages 89—100

DOI https://doi.org/10.2147/VHRM.S57116

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Malkanthi Evans,1 John A Rumberger,2 Isao Azumano,3 Joseph J Napolitano,4 Danielle Citrolo,5 Toshikazu Kamiya5

1KGK Synergize Inc, London, ON, Canada; 2The Princeton Longevity Center, Princeton, NJ, USA; 3Daiichi Fine Chemical Co, Ltd, Toyama, Japan; 4Independent Consultant, Allentown, PA, USA; 5Kyowa Hakko USA, New York, NY, USA

Abstract: High serum concentration of low-density lipoprotein cholesterol (LDL-C) is a major risk factor for coronary heart disease. The efficacy of pantethine treatment on cardiovascular risk markers was investigated in a randomized, triple-blinded, placebo-controlled study, in a low to moderate cardiovascular disease (CVD) risk North American population eligible for statin therapy, using the National Cholesterol Education Program (NCEP) guidelines. A total of 32 subjects were randomized to pantethine (600 mg/day from weeks 1 to 8 and 900 mg/day from weeks 9 to16) or placebo. Compared with placebo, the participants on pantethine showed a significant decrease in total cholesterol at 16 weeks (P=0.040) and LDL-C at 8 and 16 weeks (P=0.020 and P=0.006, respectively), and decreasing trends in non-high-density lipoprotein cholesterol at week 8 and week 12 (P=0.102 and P=0.145, respectively) that reached significance by week 16 (P=0.042). An 11% decrease in LDL-C from baseline was seen in participants on pantethine, at weeks 4, 8, 12, and 16, while participants on placebo showed a 3% increase at week 16. This decrease was significant between groups at weeks 8 (P=0.027) and 16 (P=0.010). The homocysteine levels for both groups did not change significantly from baseline to week 16. Coenzyme Q10 significantly increased from baseline to week 4 and remained elevated until week 16, in both the pantethine and placebo groups. After 16 weeks, the participants on placebo did not show significant improvement in any CVD risk end points. This study confirms that pantethine lowers cardiovascular risk markers in low to moderate CVD risk participants eligible for statins according to NCEP guidelines.

Keywords: nutritional and metabolic diseases, hypercholesterolemia, pantethine, cardiovascular diseases, dietary supplements, controlled clinical trial

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]

 

Readers of this article also read:

USP18 downregulation in peripheral blood mononuclear cells predicts nonresponse to interferon-based triple therapy in patients with chronic hepatitis C, genotype 1: a pilot study

Frankova S, Jirsa M, Merta D, Neroldova M, Urbanek P, Senkerikova R, Spicak J, Sperl J

Therapeutics and Clinical Risk Management 2015, 11:1853-1861

Published Date: 17 December 2015

Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function

Sakai T, Sato B, Hara K, Hara Y, Naritomi Y, Koyanagi S, Hara H, Nagao T, Ishibashi T

Vascular Health and Risk Management 2014, 10:591-597

Published Date: 17 October 2014

Blood and urine levels of heavy metal pollutants in female and male patients with coronary artery disease

Sponder M, Fritzer-Szekeres M, Marculescu R, Mittlböck M, Uhl M, Köhler-Vallant B, Strametz-Juranek J

Vascular Health and Risk Management 2014, 10:311-317

Published Date: 13 May 2014

Visceral obesity is not an independent risk factor of mortality in subjects over 65 years

Thomas F, Pannier B, Benetos A, Vischer UM

Vascular Health and Risk Management 2013, 9:739-745

Published Date: 22 November 2013

Causal diagrams and the cross-sectional study

Shahar E, Shahar DJ

Clinical Epidemiology 2013, 5:57-65

Published Date: 9 March 2013

Diagnosis of carotid artery stenosis with oculopneumoplethysmography alone and in combination with MRA

Elias RM, Wald JT, Kallmes DF

Vascular Health and Risk Management 2012, 8:631-639

Published Date: 23 November 2012

Rivaroxaban in atrial fibrillation

Giorgi MA, Miguel LS

Vascular Health and Risk Management 2012, 8:525-531

Published Date: 30 August 2012

Completeness of TNM cancer staging for melanoma in the Danish Cancer Registry, 2004–2009

Frøslev T, Grann AF, Olsen M, Olesen AB, Schmidt H, Friss S, Søgaard M

Clinical Epidemiology 2012, 4:5-10

Published Date: 17 August 2012