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P2RX7 Gene rs1718125 Polymorphism is Related with Postoperative Pain and Fentanyl Intake in Esophageal Cancer Patients

Authors Zheng C, Wang J, Xie S

Received 6 March 2020

Accepted for publication 20 August 2020

Published 12 November 2020 Volume 2020:13 Pages 585—589

DOI https://doi.org/10.2147/PGPM.S252798

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Martin Bluth


Cuijuan Zheng,1 Jiayu Wang,1 Shouxiang Xie2

1Department of Anesthesiology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian, Jiangsu, People’s Republic of China; 2Department of Emergency, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian, Jiangsu, People’s Republic of China

Correspondence: Shouxiang Xie Tel/Fax +86-517-80878245
Email yczcj09@sina.com

Background: Prevention and control of postoperative pains are essential, which affects the prognosis and life quality of patients. Fentanyl is a widely used opioid drug for pre-, intra- and postoperative analgesia. Identifying a patient’s genotype before surgery may help to control the fentanyl dose in the perioperative period.
Patients and Methods: This study enrolling 645 esophageal cancer (EC) patients was aimed to investigate the associations of P2RX7 gene rs1718125 polymorphism with fentanyl intake and postoperative pains in a Chinese Han population. Genotyping was accomplished by direct sequencing and polymerase chain reaction.
Results: The GA/AA genotype carriers showed lower visual analog scale scores at postoperative 0, 6 and 24 h, but not at 48 h, compared with the GG genotype. The fentanyl consumption of GG genotype was remarkably more relative to the GA/AA genotype at 6 and 24 h after treatment.
Conclusion: P2RX7 rs1718125 polymorphism is connected to the postoperative pains and fentanyl use for EC patients.

Keywords: esophageal cancer, fentanyl, P2RX7, single nucleotide polymorphism, postoperative pain

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