Back to Journals » Pharmacogenomics and Personalized Medicine » Volume 13

P2RX7 Gene rs1718125 Polymorphism is Related with Postoperative Pain and Fentanyl Intake in Esophageal Cancer Patients

Authors Zheng C, Wang J, Xie S

Received 6 March 2020

Accepted for publication 20 August 2020

Published 12 November 2020 Volume 2020:13 Pages 585—589


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Martin Bluth

Cuijuan Zheng,1 Jiayu Wang,1 Shouxiang Xie2

1Department of Anesthesiology, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian, Jiangsu, People’s Republic of China; 2Department of Emergency, The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University, Huaian, Jiangsu, People’s Republic of China

Correspondence: Shouxiang Xie Tel/Fax +86-517-80878245

Background: Prevention and control of postoperative pains are essential, which affects the prognosis and life quality of patients. Fentanyl is a widely used opioid drug for pre-, intra- and postoperative analgesia. Identifying a patient’s genotype before surgery may help to control the fentanyl dose in the perioperative period.
Patients and Methods: This study enrolling 645 esophageal cancer (EC) patients was aimed to investigate the associations of P2RX7 gene rs1718125 polymorphism with fentanyl intake and postoperative pains in a Chinese Han population. Genotyping was accomplished by direct sequencing and polymerase chain reaction.
Results: The GA/AA genotype carriers showed lower visual analog scale scores at postoperative 0, 6 and 24 h, but not at 48 h, compared with the GG genotype. The fentanyl consumption of GG genotype was remarkably more relative to the GA/AA genotype at 6 and 24 h after treatment.
Conclusion: P2RX7 rs1718125 polymorphism is connected to the postoperative pains and fentanyl use for EC patients.

Keywords: esophageal cancer, fentanyl, P2RX7, single nucleotide polymorphism, postoperative pain

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]