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Optimal Management of Partial Thickness Rotator Cuff Tears: Clinical Considerations and Practical Management

Authors Thangarajah T , Lo IK

Received 7 December 2021

Accepted for publication 17 February 2022

Published 26 February 2022 Volume 2022:14 Pages 59—70

DOI https://doi.org/10.2147/ORR.S348726

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Professor Clark Hung



Tanujan Thangarajah, Ian K Lo

Department of Trauma and Orthopaedic Surgery, University of Calgary, Calgary, Alberta, Canada

Correspondence: Tanujan Thangarajah, Department of Trauma and Orthopaedic Surgery, University of Calgary, Calgary, Alberta, Canada, Email [email protected]

Abstract: Partial thickness rotator cuff tears have been diagnosed with increased frequency due to heightened awareness and an improvement in diagnostic modalities. When > 50% of the tendon thickness has ruptured, intra-tendinous strain of the residual tendon increases. Surgery is generally confined to patients who have failed non-operative measures and have persistent symptoms. The rationale for repairing partial thickness tears lies in their limited self-healing capacity, and propensity to enlarge over time and progress to a full thickness defect. Although tear debridement and acromioplasty can improve pain and function, tear progression can occur, in addition to worse results being noted in bursal-sided defects. Several surgical strategies have been recommended but there is a lack of evidence to advocate one form of treatment over another. The aim of this narrative review is to discuss the treatment options for partial thickness tears of the rotator cuff.

Keywords: arthroscopy, rotator cuff, shoulder pain, tendon injuries

Introduction

Partial thickness rotator cuff tears (PTRCTs) have been diagnosed with increased frequency due to heightened awareness and an improvement in diagnostic modalities.1 The overall prevalence of rotator cuff abnormalities increases with age, from 9.7% in those 20 years and younger, to 62% in those aged 80 years and older.2 Similarly, PTRCTs are more likely to occur in older individuals and have an estimated prevalence of between 13% and 32%.3–6 The true scale of the problem may be greater than originally reported due to the difficulties in identifying intra-tendinous lesions, which account for over half of partial thickness defects.7

Non-operative management can improve clinical outcomes but do not address the underlying tear.8 Over 40% of asymptomatic partial thickness defects progress to full thickness tears within three years.9 In those who fail to respond to non-operative measures, surgery may offer a solution. Current operative strategies are governed by the thickness of the tendon affected, with greater than 50% involvement traditionally considered as the point at which a repair should be considered.10 This is primarily due to the significant increase in intra-tendinous strain observed beyond this, and its influence on tear propagation.1,10

Of the surgical options described in the literature, the simplest entails a subacromial decompression (acromioplasty and bursectomy) and tear debridement. On the opposite end of the spectrum, the most aggressive strategy involves converting the defect to a full thickness tear and repairing it. The principal limitation of this approach is that excising the native tendon can permanently alter the footprint and disrupt the normal length–tension relationship of the musculotendinous unit.11 Trans-tendinous repair offers an intermediate solution and has gained in popularity but has not shown superiority to a conversion to full thickness tear and repair, and increases the risk of pain and stiffness.12 More recently, there has been a growing interest in the use of innovative biological solutions such as highly porous bioinductive bovine collagen implants. Although early results of this resorbable graft are encouraging, with an improvement in clinical outcome and increased mean tendon thickness, no long-term comparative studies have been conducted.13

The purpose of this narrative review is to discuss the treatment options for partial thickness tears of PTRCTs.

Aetiology and Pathogenesis

PTRCTs are likely to occur as the end result of a common pathway that is mediated by both intrinsic and extrinsic factors.14 Intrinsic factors comprise age-related microscopic changes (hypocellularity, fascicular thinning, dystrophic calcification, and accumulation of granulation tissue), hypovascularity, and alterations in intra-tendinous strain.4,5,15–17 Extrinsic factors encompass structural causes such as subacromial impingement, micro-instability, and internal impingement (contact between the postero-superior aspect of the glenoid and the under-surface of the rotator cuff).18–20 Other causative factors include Trauma, metabolic factors (diabetes, hypolipidaemia, and metabolic syndrome), and a genetic predisposition.7,21,22 The articular part of the rotator cuff is particularly vulnerable to tearing because of its proximity to the zone of hypovascularity located lateral to the rotator cable. Its less organised collagen structure has an ultimate stress to failure half that of the bursal surface.23

Clark and Harryman demonstrated that the rotator cuff insertion consisted of five distinct histological layers.24 The first layer is the superficial coracohumeral ligament. The second and third layers contain the tendinous fibres of the rotator cuff, and the remaining fourth and fifth layers comprise loose connective tissue and the shoulder joint capsule. This arrangement predisposes to the development of internal shear forces between the layers that leads to a rise in intra-tendinous strain and further tissue degeneration, impaired healing and tear propagation.16,25–28 Intra-tendinous strain can additionally be elevated during shoulder abduction and can potentially result in an articular-sided tear.16,25 This mechanism has been cited in the development of PTRCTs in overhead-throwing athletes, whose rotator cuff tendons are subjected to repetitive and powerful eccentric forces.1

Yamanaka and Matsumoto29 reported that after one year, 28% of PTRCTs progressed to full thickness defects and 80% increased in size. This though may represent an overestimation, with more recent reports suggesting that at four years, no significant progression occurs in 76% of cases and only 8% of patients develop a full thickness tear.8 In a longer-term follow-up study by Ranebo et al,30 43 patients with PTRCTs were reviewed at a minimum of 20 years after an acromioplasty without repair. The majority of tears did not propagate (42%) and cuff tear arthropathy rarely occurred (7% of cases). Tear progression is associated with the percentage of the tendon thickness involved. In patients with tears involving over 50% of the tendon thickness, 55% exhibited progression compared to those with less than 50% of the thickness involved who had tear progression in 14% of cases.8 While some clinical studies suggest that PTRCTs do not spontaneously heal, basic science studies have demonstrated an active cellular response in these defects that implies some self-healing properties.31–33

Classification

PTRCTs are defined according to their location (articular, bursal, and intra-tendinous), tendons involved, and the percentage of the tendon thickness affected.1 The widely used Ellman classification incorporates location, depth (grade 1, <3 mm deep; grade 2, 3–6 mm deep; grade 3, >6 mm deep), and area (mm2) to define the tear. Despite the popularity of this system, inter-observer reliability is poor and it fails to consider tissue quality and aetiology (acute vs chronic vs acute-on-chronic).7,34–36

In overhead athletes, articular-sided injuries most often involve the posterior supraspinatus and anterior infraspinatus.37 This is thought to arise due to internal impingement and/or anatomical deficiencies in the articular portion of the rotator cuff such as hypovascularity and disorganised collagen arrangement.5,24,38 Millstein and Snyder coined the PASTA lesion to describe a partial articular supraspinatus tendon avulsion, following which it was recognised as a distinct pathological entity.39 Conway expanded on this variant by describing a partial articular tear with intra-tendinous extension (PAINT lesion) and an intact footprint.40 Bursal-sided tears can be associated with subacromial impingement due to a bony spur, and are thus considered more of a degenerative lesion.18 However, evidence for this is limited particularly since an acromial spur is in fact a traction enthesophyte within the coracoacromial ligament that occurs as the humeral head passes below it, thus placing the ligament under increased tension.41

Non-Operative Treatment

Non-operative treatment is a viable first-line option for partial thickness tears owing to their low risk of tear progression, fatty infiltration, and muscle atrophy.29 Physiotherapy, anti-inflammatory medication, and activity modification are the first-line approach. A formal exercise regime should focus on scapulo-humeral dynamics, postural control, and posterior capsular stretching. Corticosteroid injections offer an appealing solution to residual pain but increase the risk of complications and revision surgery following rotator cuff repair.42 Lo et al8 followed-up 37 patients who underwent non-operative treatment for a PTRCT. After a mean follow-up of 46 ± 7 months there was an improvement in functional outcome, with 76% of tears not exhibiting a progression in size.

Indications for Surgery

The rationale for repairing partial thickness tears lies in their limited self-healing capacity, and propensity to enlarge over time and progress to a full thickness defect.29,32,33,43,44 Surgery is generally confined to those who have failed non-operative measures and have persistent pain and/or disability. A number of operative strategies have been described but the choice has traditionally been based upon whether the patient will benefit from a formal repair or a less invasive procedure such as a debridement ± acromioplasty.

Several factors influence the decision to operate (eg patient age, activity level, concomitant pathology, occupation) but it is the percentage of tendon thickness involved that is often regarded as the most important consideration.1,7 The rationale for this emanates from the retrospective study carried out by Weber et al45 in which patients with tearing of >50% of their tendon thickness demonstrated superior clinical outcomes [improvement in the University of California, Los Angeles Shoulder (UCLA) Rating Scale and lower reoperation rate] with mini-open repair compared to arthroscopic acromioplasty alone. This has subsequently been supported by a number of biomechanical studies that have shown an increase in intra-tendinous strain of the residual tendon substance when >50% of the thickness has been ruptured.10,28

Arthroscopic Procedures

An arthroscopic-based operation has the distinct advantage over open surgery in that it affords a comprehensive evaluation of the intra-articular and subacromial spaces. There is currently insufficient evidence to advocate one specific procedure for the treatment of high-grade partial thickness tears, however irrespective of the technique employed, an improvement in functional outcome can reliably be achieved.46 Current surgical strategies include tear debridement with or without acromioplasty, conversion to full-thickness defect and repair, in situ repair, and biological augmentation strategies.

Tear Debridement with or without Acromioplasty

Tears that affect <50% of the tendon thickness can be managed successfully with a debridement ± acromioplasty (Table 1).30,47–52 Budoff et al48 reviewed 60 patients who had undergone an isolated rotator cuff debridement without an acromioplasty for a PTRCT. Using the UCLA Rating Scale there were 79% excellent or good results at an average of 114 months follow-up, and 77% had no or very little pain.

Table 1 Clinical Outcome and Retear Rate Following Debridement +/- Acromioplasty of Partial Thickness Rotator Cuff Tears

Favourable results have not been reported ubiquitously though. Kartus et al51 followed-up 26 patients who underwent an acromioplasty in conjunction with a tear debridement. At 101 months, 35% of partial thickness tears had progressed to full thickness defects. Additionally, the average Constant score was 20 points lower than the contralateral shoulder and worse for bursal-sided tears. The detrimental effect of bursal-sided lesions was additionally noted by Cordasco et al.,52 who evaluated 76 patients that had a debridement and acromioplasty for a PTRCT. After 53 months, failure was only observed in 3% of patients with articular-sided tears compared to 29% of those with a bursal-sided defect.

The variability of arthroscopic debridement has also been observed in the athletic population. For athletes under the age of 40 years who were treated with a subacromial decompression (60% had an acromioplasty), a satisfactory outcome was noted in 86% of acute traumatic cases with an overall 64% return to sport.53

Conversion to Full-Thickness Defect and Repair

Conversion to a full thickness tear removes excess devitalised tissue and allows standard repair techniques to be utilised (Figure 1 and Table 2). Although this may be technically easier than some in situ repair techniques, removing native tendon tissue may alter the biomechanics of the rotator cuff. Moreover, resecting lateral tendon tissue may lead to a non-anatomic repair and length-tension mismatches.19 Nonetheless, encouraging results have been reported and are characterised by an improvement in range of movement, strength, pain, and function.54–56 Fama et al54 reviewed 87 patients who underwent conversion to a full thickness tear at a median follow-up of five years. Patient satisfaction was high and accompanied by a significant improvement in both the Constant score (53.5 to 94) and pain. Although similar results have been additionally been reported in other studies evaluating the results following full-thickness conversion,55–57 a recent prospect randomised controlled trial by Wang et al58 demonstrated no difference in patient-reported outcome measures and retear rates on MRI between isolated subacromial decompression and full-thickness conversion at 18 months follow-up.

Table 2 Clinical Outcome and Retear Rate Following Conversion to a Full Thickness Defect and Subsequent Repair of a Partial Thickness Rotator Cuff Tears

Figure 1 Right shoulder arthroscopy oriented in the beach chair position viewing from the posterior portal. (A) A bursal surface tear is identified within the subacromial space and converted into a full thickness tear using a knife inserted through a mid-lateral portal. (B) The tear is exposed using electrocautery. (C) The electrocautery device is inserted through the tear in the subacromial space so that it can be identified within the glenohumeral joint. (D) Footprint preparation is completed in the glenohumeral joint. (E) Rotator cuff repair is completed from within the subacromial space using a standard technique, such as the double row used here.

In situ Repair

In situ transtendinous repair techniques are commonly performed on articular sided tears and preserve the lateral tendon tissue of the rotator cuff whilst restoring medial tendon-bone contact (Figure 2 and Table 3).7,59,60 Maintaining viable tissue in this manner has the theoretical advantage of permitting a more anatomical reconstruction of the enthesis. Zafra et al61 followed up 50 patients for a mean of 32.5 months who had either a single- or double-row in situ repair for a partial thickness tear. Both groups demonstrated an improvement in the ASES score, Constant score, and pain. No significant inter-group differences were noted and three retears were identified on MRI. Despite these encouraging results, the limitation of in situ repair is the risk of a tension mismatch between the articular and bursal sides due to over-tensioning, and the increased pain and stiffness that may result.12,62 For example, in a study of 489 consecutive rotator cuff repairs, Huberty et al62 determined that an in situ repair was a significant risk factor for the development of postoperative stiffness in the short-term. To mitigate this, further surgical techniques have been developed to perform an isolated reduction of the articular portion of the tendon.63 However, the advantage of this technique has not been demonstrated over other trans-tendon repairs. Overall, while good results can be obtained using in situ techniques, there is an increase the risk of residual symptoms following surgery in patients with greater tendon retraction of the entire tendinous unit, advanced age, atraumatic history, and increased tendon retraction with minimal footprint exposure at surgery.64

Table 3 Clinical Outcome and Retear Rate Following Arthroscopic in situ Transtendinous Repair of a Partial Thickness Rotator Cuff Tears

Figure 2 Right shoulder arthroscopy oriented in the beach chair position viewing through the posterior portal. (A) A partial thickness tear on the articular side is identified (black arrow) from within the glenohumeral joint. (B) The footprint is exposed after debriding the tear. (C) The intact bursal surface is seen from within the subacromial space. (D) A suture anchor is inserted transtendon through the rotator cuff into the medial aspect of the footprint, whilst viewing from the glenohumeral joint. (E) The sutures are tied from within the subacromial space, and in this case incorporated into a double row fixation construct.

Conversion versus in situ Repairs

In a cadaveric study comparing the biomechanical performance of transtendon in situ repair with tear completion and double-row repair, the in situ repair demonstrated significantly less gap formation and greater ultimate failure strength under cyclical loading conditions.19 Similar results were noted in an ovine model, with in situ repair resulting in the highest footprint contact pressures and ultimate load to failure.65 Alternatively, in a rabbit model comparing the two techniques, Pulatkan et al66 demonstrated that tear completion followed by repair led to a significantly greater load to failure and superior histological results. Despite these biomechanical advantages the results of clinical studies have been variable (Table 4).67–70

Table 4 Clinical Outcome and Retear Rate Following a Comparison Between Transtendon in situ Repair and Tear Completion with Subsequent Repair, for Partial Thickness Rotator Cuff Tears

Castagna et al68 randomized 74 patients with an articular surface tear to undergo either an in situ repair or conversion to a full thickness defect and repair. At two years follow-up, there was an improvement in both the Constant score and visual analogue scale for pain in both groups, without any significant inter-group differences. In a further randomized study comparing these two surgical strategies, Shin et al69 similarly showed an improvement in clinical outcomes following surgery. In the tear completion group, functional recovery was faster, and pain was significantly less for the first three months following surgery. Although not significantly different, concerns though were raised regarding retears, which occurred in 8% (2/24) of the tear completion group and none from the in-situ repair group. In contrast, a further prospectively randomized study by Franceschi et al70 showed no significant difference between retear rates as observed on MRI.

Biological Augmentation

Cell-Based Strategies

Platelet-rich plasma (PRP) and stem cells are the two predominant cell-based strategies that have been specifically evaluated in the context of PTRCTs.71–74 PRP is one of the most common injectable agents for musculoskeletal disease and enhances the early phases of tissue healing by increasing the local concentration of platelets and growth factors such as platelet-derived growth factor, vascular-derived growth factor, transforming growth factor β, and epidermal growth factor.75 In a double-blind randomized controlled trial, Kwong et al71 compared PRP to corticosteroid injections for PTRCTs. At three months after injection, the PRP group had greater improvement in their VAS and WORC scores. This benefit was not sustained at 12 months, and no difference was noted in either the failure rate or rate of conversion to surgery between groups. Cai et al73 combined PRP with sodium hyaluronate (SH) for the treatment of partial thickness tears and found that this yielded better results (higher Constant, ASES and VAS scores) than either of the treatments in isolation. Additionally, MRI showed that the tear size significantly decreased in size in both the PRP and SH + PRP groups. In a recent meta-analysis of all randomized controlled trials evaluating PRP as a non-operative treatment for rotator cuff tears, there was limited evidence to advocate its widespread use because in the short-term it was not efficacious, and did not result in better outcomes (functional outcome, pain scores, and range of motion) when compared to an exercise regime.76

Stem cell treatment for rotator cuff tears is a promising development because they have been shown to result in an anti-inflammatory response, improved tendon regeneration, optimised collagen fibre arrangement, higher load-to-failure, and higher tensile strength.77–79 Hurd et al74 carried out a randomized controlled pilot study to compare the effects of adipose-derived regenerative cells (ADRCs) and corticosteroid injections on PTRCTs. At one-year follow-up, there were no adverse reactions and the ADRC group demonstrated a significantly higher ASES score. In a non-randomized controlled trial comparing the effects of an exercise regime to PRP combined with bone marrow aspirate (BMAC-PRP complex) on PTRCTs, the experimental group demonstrated a significantly greater improvement in VAS and ASES scores compared to controls at three months. Tear size decreased after BMAC-PRP injection although this did not significantly differ from controls.72

Scaffolds

Due to some variable results associated with current surgical strategies as well as the restrictive post-operative rehabilitation that is often required, increased attention has been given to biological adjuncts. Bioinductive collagen implants have been shown in an ovine study to induce the formation of well-organized collagen fibres oriented in the direction of load and a fibrocartilaginous transition across the enthesis.80 Although the graft had resorbed by six months with no adverse reactions, this was accompanied by an additional 2.5 mm of new tissue growth compared to controls. Finite-element analysis has revealed that by increasing the thickness of the supraspinatus tendon by 2 mm on the bursal surface, the peak intra-tendinous strain can be decreased by 47% in bursal-sided partial-thickness tears and by 40% in articular-sided partial-thickness tears.81

Clinical studies evaluating this scaffold demonstrate a significant improvement in pain, functional outcome, with a corresponding increased tendon thickness and favourable safety profile.13,82–84 Importantly, an accelerated rehabilitation programme can be used with few restrictions, particularly if an isolated bioinductive collagen implant is utilized without a concomitant repair.82 Although this biomaterial has provided encouraging results in the short-term, it must be rigorously compared to the more cost-effective options outlined above (subacromial decompression, in situ repair, and conversion to a full-thickness defect and repair) before it can be recommended for routine clinical use.

Influence of Tear Location (Articular vs Bursal) on Clinical Outcomes

The articular surface of the rotator cuff has an ultimate stress to failure that is approximately half that of its corresponding bursal side, with thinner and less uniformly arranged collagen fibres.23 Intrinsic degenerative changes, that often occur with increasing age, have therefore been suggested to represent the predominant factor contributing to the occurrence of articular-sided tears. Bursal-sided tears alternatively, have traditionally been thought to arise from extrinsic mechanical impingement from a subacromial spur emanating from the coracoacromial ligament, although little evidence exists to support this theory.1,41 Based on their differing aetiologies, it has been speculated that a difference could exist in the clinical outcomes between articular- and bursal-sided PTRCTs. In a recent retrospective comparative study though, no difference was demonstrated in clinical outcomes (range of motion, pain, outcome scoring) between articular- and bursal-sided tears.85

Conclusions

Partial thickness tears of the rotator cuff are a common cause of shoulder pain and disability. Surgery is confined to those experiencing severe symptoms despite non-operative measures, and for tears involving greater than 50% thickness. A number of surgical strategies have been described, but there is insufficient evidence to advocate one repair technique over another. Future research should focus on determining the most effective surgical solution (subacromial decompression versus conversion to full thickness tear and repair versus in situ repair) and explore the precise role of biological approaches (eg bioinductive collagen implants and cell-based strategies).

Disclosure

The authors report no conflicts of interest in this work.

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