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Optical coherence tomography retinal nerve fiber layer analysis in eyes with long axial lengths

Authors Patel SB, Reddy N, Lin X, Whitson JT

Received 9 January 2018

Accepted for publication 6 March 2018

Published 3 May 2018 Volume 2018:12 Pages 827—832

DOI https://doi.org/10.2147/OPTH.S162023

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 4

Editor who approved publication: Dr Scott Fraser


Sagar B Patel,1,2 Nisha Reddy,2 Xihui Lin,1,2 Jess T Whitson1,2

1Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX, USA; 2Department of Ophthalmology, University of Texas Southwestern Medical School, Dallas, TX, USA

Purpose: To evaluate the relationship between axial length (AL) and retinal nerve fiber layer (RNFL) profile and to characterize differences in optical coherence tomography RNFL of myopic glaucomatous eyes compared to nonglaucomatous eyes.
Methods:
Retrospective chart review of 170 eyes of 89 subjects with optical biometry and optical coherence tomography RNFL assessment was conducted.
Results: Temporal RNFL thickness showed no association with AL in either glaucomatous or nonglaucomatous eyes. Nasal thinning was most strongly associated with glaucoma in myopic eyes. Both myopic glaucomatous and nonglaucomatous eyes had a mean RNFL thickness of 16–22 µm thinner than mean RNFL thickness of normal AL eyes.
Conclusion: An average of 16–22 µm thinning of RNFL compared to nomogram can be tolerated in patients with long AL. Prominent nasal thinning likely represents changes from axial elongation. Temporal RNFL thinning in those with long AL tends to be mild, and significant thinning should raise suspicion for glaucoma.

Keywords: myopia, axial length, ocular coherence tomography retinal nerve fiber layer (OCT RNFL), glaucoma



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